about
Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancerTelomeres acquire embryonic stem cell characteristics in induced pluripotent stem cellsMammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sitesATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase.Telomerase reverse transcriptase delays aging in cancer-resistant mice.The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidenceTPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in miceThe longest telomeres: a general signature of adult stem cell compartments.Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in miceTelomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction.Generation of mice with longer and better preserved telomeres in the absence of genetic manipulationsLocalization-dependent and -independent roles of SLX4 in regulating telomeres.ATRX driver mutation in a composite malignant pheochromocytoma.The copper-chelating agent, trientine, suppresses tumor development and angiogenesis in the murine hepatocellular carcinoma cells.Desmopressin inhibits lung and lymph node metastasis in a mouse mammary carcinoma model of surgical manipulation.Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres.AAV9-mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K-Ras-induced lung cancerA G-Quadruplex Ligand with 10000-Fold Selectivity over Duplex DNAExpression of mTert in primary murine cells links the growth-promoting effects of telomerase to transforming growth factor-β signalingPorphyrin Derivatives for Telomere Binding and Telomerase InhibitionIrreversible telomere shortening by 3'-azido-2',3'-dideoxythymidine (AZT) treatment
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description
hulumtuese
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researcher
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wetenschapper
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հետազոտող
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name
Agueda M Tejera
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Agueda M Tejera
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Agueda M Tejera
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Agueda M Tejera
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type
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Agueda M Tejera
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Agueda M Tejera
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Agueda M Tejera
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Agueda M Tejera
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prefLabel
Agueda M Tejera
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Agueda M Tejera
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Agueda M Tejera
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Agueda M Tejera
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6602494477
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0000-0002-6703-9466