The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFbeta signal transduction. - Wikidata - awgldk - TriplyDB

The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFbeta signal transduction.

The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFbeta signal transduction.

http://www.wikidata.org/entity/Q34016197

about

Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2 GRK2: multiple roles beyond G protein-coupled receptor desensitization Reversible Human TGF-β Signal Shifting between Tumor Suppression and Fibro-Carcinogenesis: Implications of Smad Phospho-Isoforms for Hepatic Epithelial-Mesenchymal Transitions GRK2 in the heart: a GPCR kinase and beyond Breast cancer anti-estrogen resistance 3 inhibits transforming growth factor β/Smad signaling and associates with favorable breast cancer disease outcomes Engulfment protein GULP is regulator of transforming growth factor-β response in ovarian cells.G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression TGF-β/Smad signaling during hepatic fibro-carcinogenesis (review).Multiple scaffolding functions of {beta}-arrestins in the degradation of G protein-coupled receptor kinase 2 G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4 Smad phosphoisoform signaling specificity: the right place at the right time G protein-coupled receptor kinases: more than just kinases and not only for GPCRs Smad phosphoisoform signals in acute and chronic liver injury: similarities and differences between epithelial and mesenchymal cells.Regulation of Smad activities.Monitoring of phosphorylated peptides by radioactive assay and matrix-assisted laser desorption-ionization time-of-flight mass spectrometry.p21-Activated kinase 2 (PAK2) inhibits TGF-β signaling in Madin-Darby canine kidney (MDCK) epithelial cells by interfering with the receptor-Smad interaction Inhibition of G-protein-coupled receptor kinase 2 (GRK2) triggers the growth-promoting mitogen-activated protein kinase (MAPK) pathway.The Dual Role of TGFβ in Human Cancer: From Tumor Suppression to Cancer Metastasis Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2 HS-173, a novel PI3K inhibitor suppresses EMT and metastasis in pancreatic cancer.The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets Role of Smads in TGFβ signaling.The connection between GRKs and various signaling pathways involved in diabetic nephropathy.Differential Regulation of TGF-β/Smad Signaling in Hepatic Stellate Cells between Acute and Chronic Liver Injuries.Post-translational regulation of TGF-β receptor and Smad signaling.Link between cancer and Alzheimer disease via oxidative stress induced by nitric oxide-dependent mitochondrial DNA overproliferation and deletion Linker phosphorylation of Smad3 promotes fibro-carcinogenesis in chronic viral hepatitis of hepatocellular carcinoma.Multiple functions of G protein-coupled receptor kinases Role of G protein-coupled receptor kinase 2 in tumoral angiogenesis.EIF3D promotes gallbladder cancer development by stabilizing GRK2 kinase and activating PI3K-AKT signaling pathway Growth inhibition of human hepatocellular carcinoma cells by overexpression of G-protein-coupled receptor kinase 2.Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis Negative regulation of VEGF signaling in human coronary artery endothelial cells by G protein-coupled receptor kinase 5 The Role of G Protein-coupled Receptor Kinases in Cancer.Role of amino acid residues surrounding the phosphorylation site in peptide substrates of G protein-coupled receptor kinase 2 (GRK2).Peptide substrates for G protein-coupled receptor kinase 2.

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The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFbeta signal transduction.

http://www.wikidata.org/entity/Q34016197

description

2005 nî lūn-bûn

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2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

The G protein-coupled receptor ...... f TGFbeta signal transduction.

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The G protein-coupled receptor ...... f TGFbeta signal transduction.

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The G protein-coupled receptor ...... f TGFbeta signal transduction.

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type

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The G protein-coupled receptor ...... f TGFbeta signal transduction.

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The G protein-coupled receptor ...... f TGFbeta signal transduction.

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The G protein-coupled receptor ...... f TGFbeta signal transduction.

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prefLabel

The G protein-coupled receptor ...... f TGFbeta signal transduction.

@ast

The G protein-coupled receptor ...... f TGFbeta signal transduction.

@en

The G protein-coupled receptor ...... f TGFbeta signal transduction.

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SJ.EMBOJ.7600794

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The EMBO Journal

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The G protein-coupled receptor ...... f TGFbeta signal transduction.

@en

P2093

Barry I Posner

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Eftihia Cocolakis

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Jean-Jacques Lebrun

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Joanne Ho

http://www.w3.org/2001/XMLSchema#string

Stéphane A Laporte

http://www.w3.org/2001/XMLSchema#string

Victor M Dumas

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P2860

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling

Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit

Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II

Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element

GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling

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18

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24

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2005-08-25T00:00:00Z

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7639870

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16121194

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G protein-coupled receptor

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1224684

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