Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitus
about
Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptideToxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice.Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.A missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific mannerPriming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity.Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer PeptideEtiopathogenesis of insulin autoimmunity.The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice.Identification of novel IGRP epitopes targeted in type 1 diabetes patients.Identification of Candidate Tolerogenic CD8(+) T Cell Epitopes for Therapy of Type 1 Diabetes in the NOD Mouse Model.Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes.Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells.Antigen presentation events in autoimmune diabetes.Adoptive Transfer of mRNA-Transfected T Cells Redirected against Diabetogenic CD8 T Cells Can Prevent Diabetes.Glucagon-reactive islet-infiltrating CD8 T cells in NOD mice.AMP-activated protein kinase regulates glucagon secretion from mouse pancreatic alpha cells.Peptide-based treatment for autoimmune diseases: learning how to handle a double-edged sword.Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice.Antibodies to post-translationally modified insulin in type 1 diabetes.Identification of a naturally processed cytotoxic CD8 T-cell epitope of coxsackievirus B4, presented by HLA-A2.1 and located in the PEVKEK region of the P2C nonstructural protein.Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice.Functional inhibition related to structure of a highly potent insulin-specific CD8 T cell clone using altered peptide ligands.Immunology: Insulin auto-antigenicity in type 1 diabetes.Structural definition of the H-2Kd peptide-binding motif.APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice.
P2860
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P2860
Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitus
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Analysis of structure and func ...... ptide of insulin bound to H-2K
@nl
Analysis of structure and func ...... in-dependent diabetes mellitus
@ast
Analysis of structure and func ...... in-dependent diabetes mellitus
@en
type
label
Analysis of structure and func ...... ptide of insulin bound to H-2K
@nl
Analysis of structure and func ...... in-dependent diabetes mellitus
@ast
Analysis of structure and func ...... in-dependent diabetes mellitus
@en
prefLabel
Analysis of structure and func ...... ptide of insulin bound to H-2K
@nl
Analysis of structure and func ...... in-dependent diabetes mellitus
@ast
Analysis of structure and func ...... in-dependent diabetes mellitus
@en
P2093
P2860
P356
P1476
Analysis of structure and func ...... in-dependent diabetes mellitus
@en
P2093
Antonis K Moustakas
Charles A Janeway
P2860
P304
P356
10.1073/PNAS.072037299
P407
P577
2002-04-09T00:00:00Z