about
The binding of antigenic peptides to HLA-DR is influenced by interactions between pocket 6 and pocket 9.Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitusDifferential binding of pyruvate dehydrogenase complex-E2 epitopes by DRB1*08:01 and DRB1*11:01 Is predicted by their structural motifs and correlates with disease risk.Molecular properties of HLA-DQ alleles conferring susceptibility to or protection from insulin-dependent diabetes mellitus: keys to the fate of islet beta-cells.Trans heterodimer between two non-arthritis-associated HLA alleles can predispose to arthritis in humanized miceZinc transporter 8 autoantibodies and their association with SLC30A8 and HLA-DQ genes differ between immigrant and Swedish patients with newly diagnosed type 1 diabetes in the Better Diabetes Diagnosis studyDominance of an alternative CLIP sequence in the celiac disease associated HLA-DQ2 molecule.Use of MHC II structural features in the design of vaccines for organ-specific autoimmune diseases.Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis.Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire.Gluten-specific T cells cross-react between HLA-DQ8 and the HLA-DQ2α/DQ8β transdimer.Interplay between genetics and the environment in the development of celiac disease: perspectives for a healthy life.The spectrum of HLA-DQ and HLA-DR alleles, 2006: a listing correlating sequence and structure with function.Specific monoclonal antibodies against the surface of rat islet beta cells.Peptide analysis, stability studies, and structural modeling explain contradictory peptide motifs and unique properties of the NOD mouse MHC class II molecule H2-A(g7).Crossreactivity to vinculin and microbes provides a molecular basis for HLA-based protection against rheumatoid arthritis.The increased ability to present citrullinated peptides is not unique to HLA-SE molecules: arginine-to-citrulline conversion also enhances peptide affinity for HLA-DQ molecules.The destructive action of IL-1alpha and IL-1beta in IDDM is a multistage process: evidence and confirmation by apoptotic studies, induction of intermediates and electron microscopy.IL-6-mediated MHC class II induction on RIN-5AH insulinoma cells by IFN-gamma occurs via the G-protein pathwayDRB1*12:01 presents a unique subset of epitopes by preferring aromatics in pocket 9HLA-DR1001 presents "altered-self" peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets.Definition of the peptide binding motif within DRB1*1401 restricted epitopes by peptide competition and structural modelingFunctional inhibition related to structure of a highly potent insulin-specific CD8 T cell clone using altered peptide ligands.Mechanism of action of prothymosin alpha in the human autologous mixed lymphocyte response.Mutational analysis of critical residues determining antigen presentation and activation of HLA-DQ0602 restricted T-cell clones.Modulation of T cell response to hGAD65 peptide epitopes.T-cell recognition of HLA-DQ2-bound gluten peptides can be influenced by an N-terminal proline at p-1.Type 1 diabetes as an autoimmune disease: the evidence.Regulation of catalytic behaviour of hydrolases through interactions with functionalized carbon-based nanomaterialsDisabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptideStructural analysis of two HLA-DR-presented autoantigenic epitopes: crucial role of peripheral but not central peptide residues for T-cell receptor recognitionDetermination of the retinal/protein molar ratios for the purple membranes of Halobacterium halobium and Halobacterium cutirubrumComparative studies on the fine structure of purple membrane from Halobacterium Cutirubrum and Halobacterium HalobiumResponse to commentary by Pujol-Borrell and BottazzoSoluble interleukin 2 receptor molecules in the serum of patients with autoimmune diseasesOrientations of the retinyl and the heme chromophores in the brown membrane of Halobacterium halobiumNovel structural features of the human histocompatibility molecules HLA-DQ as revealed by modeling based on the published structure of the related molecule HLA-DRUnique peptide binding characteristics of the disease-associated DQ(alpha 1*0501, beta 1*0201) vs the non-disease-associated DQ(alpha 1*0201, beta 1*0202) moleculeModelling of the MHC II allele I-A(g7) of NOD mouse: pH-dependent changes in specificity at pockets 9 and 6 explain several of the unique properties of this moleculeRGD sequences in several receptor proteins: novel cell adhesion function of receptors?
P50
Q33772455-465F18C7-0036-4D21-82D7-3CCF4FC32733Q34025467-2C6ADB7C-0F21-46A3-A235-357550EADAB1Q34643140-4A1B57E9-3095-4B0A-9715-34D3DD34B874Q34737266-B7383423-7E6A-4A85-B12C-70AE44265DEEQ35019501-9CE3D59C-577C-4933-8AC8-B6E3B647455DQ36249785-BC6A85D0-3036-4239-8426-29E184A5E8A7Q36800315-1B0C75FA-CC92-4E8B-B043-6E7E67E25DA7Q37622342-6BD26FFE-B89D-40F1-8897-FA09A83A2C57Q38628324-A947E9F2-EDAD-4D80-98C4-330A0F379520Q39425320-D5ACE75E-C33A-4357-AC8A-A100519632ABQ39455520-18E09F07-48EC-4C06-AFFF-43D3F6064A2BQ39947155-DF48D511-133A-46E1-8FB5-2D6BDBDDCEA2Q40213716-8AF6B344-57E3-498B-B4B6-3898FBF7FE87Q40697924-00CDF52C-9DEA-441D-B552-C3418E88D017Q40706980-C8623632-3CE3-413C-B1BB-9E33732F223CQ40975154-C6E3D517-D381-4EE1-9941-DF8E718201F2Q41661241-2CD7AC93-C245-411B-B3B7-BA278BE81D01Q42001469-E179AA90-6865-4ACB-A117-DFF8543AB5E0Q42023740-9052D122-7871-4EF5-8292-D91DA9380664Q42323079-B2D19CC2-42EC-4488-8EB7-57BB9548769FQ42412117-8CEAB965-01CD-456D-84FB-EA4AB0061F0AQ42684203-6D6146E3-2230-489E-BFE5-538AB4FFE7E5Q42735278-97AC11F1-D7F9-4AE3-A4C5-8BBC1F26EE7DQ44547355-3C908B2B-A164-45B3-8193-223A91BF668BQ44886485-16BFFE12-4AE7-4CE7-B9C9-C8C769CCDD61Q44888019-02E870F6-C589-4897-83A0-B93DA751237BQ45267978-D9CB2926-D7D6-4ACE-9C6C-503FD7BDDEC0Q50474708-DCFFA9A8-FD62-404E-AD0F-A0F82CE2492AQ57189264-665505C5-0044-44F0-A313-995711925A9BQ57607827-90C8B352-E416-47BA-8926-68A531DB73B9Q60609058-AE5CDD1B-8706-4657-9DD1-8EF3EB53BD9EQ67338653-F58BE1CD-E46D-4708-8A6B-F4872330091AQ67405578-87715C52-8EF5-48FD-BEDE-D42BDB392EF5Q69515962-4EFF02E0-E402-4C8F-A9FF-E0E26C51775CQ69735787-6D819354-3AFB-4D3F-8F5F-0633F2CB8BF9Q71099493-7439345A-6ACC-4F05-BA9A-94D63EE6A71DQ71807424-19AA096F-AE51-4CC8-8ADF-E581AC03D485Q73756468-09DC0B44-91AE-4376-833D-71773857B968Q73899577-B67A93EE-9B82-4B51-BFD9-58FE57336884Q74349433-A25FD09F-C1E1-4757-85BB-982541145EF4
P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
George K. Papadopoulos
@ast
George K. Papadopoulos
@en
George K. Papadopoulos
@es
George K. Papadopoulos
@nl
George K. Papadopoulos
@sl
type
label
George K. Papadopoulos
@ast
George K. Papadopoulos
@en
George K. Papadopoulos
@es
George K. Papadopoulos
@nl
George K. Papadopoulos
@sl
prefLabel
George K. Papadopoulos
@ast
George K. Papadopoulos
@en
George K. Papadopoulos
@es
George K. Papadopoulos
@nl
George K. Papadopoulos
@sl
P106
P1153
35461847100
P21
P31
P496
0000-0002-6944-6591