Why is PTPN22 a good candidate susceptibility gene for autoimmune disease? - Wikidata - awgldk - TriplyDB

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

http://www.wikidata.org/entity/Q34026657

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Effect of Associated Autoimmune Diseases on Type 1 Diabetes Mellitus Incidence and Metabolic Control in Children and Adolescents Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics Risk factors and primary prevention trials for type 1 diabetes A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases The thymus and rheumatology: should we care?Association of CD247 (CD3ζ) gene polymorphisms with T1D and AITD in the population of northern Sweden A functional variant of PTPN22 confers risk for Vogt-Koyanagi-Harada syndrome but not for ankylosing spondylitis.Hypothyroidism among pediatric patients with type 1 diabetes mellitus, from patients' characteristics to disease severity Coherent somatic mutation in autoimmune disease.Altered B cell signalling in autoimmunity.No association of PTPN22 polymorphisms with susceptibility to ocular Behcet's disease in two Chinese Han populations Road to fulfilment: taming the immune response to restore vision.Hashimoto's Thyroiditis: From Genes to the Disease.Genetic variation and coronary atherosclerosis in patients with systemic lupus erythematosus Altered B cell homeostasis and toll-like receptor 9-driven response in type 1 diabetes carriers of the C1858T PTPN22 allelic variant: implications in the disease pathogenesis The TT genotype of the STAT4 rs7574865 polymorphism is associated with high disease activity and disability in patients with early arthritis.Systems level analysis of systemic sclerosis shows a network of immune and profibrotic pathways connected with genetic polymorphisms.PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes.Integrating virtual and biochemical screening for protein tyrosine phosphatase inhibitor discovery.Biomarkers predicting a need for intensive treatment in patients with early arthritis STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms influence the risk of developing juvenile idiopathic arthritis in Han Chinese patients.PTPN22: the archetypal non-HLA autoimmunity gene.Towards systemic sclerosis and away from primary biliary cirrhosis: the case of PTPN22.Effect of the PTPN22 and INS risk genotypes on the progression to clinical type 1 diabetes after the initiation of β-cell autoimmunity Genetics of serum concentration of IL-6 and TNFα in systemic lupus erythematosus and rheumatoid arthritis: a candidate gene analysis.Association between PTPN22 C1858T polymorphism and alopecia areata risk Negative regulation of TLR signaling in myeloid cells--implications for autoimmune diseases.Autoimmune Variant PTPN22 C1858T Is Associated With Impaired Responses to Influenza Vaccination.Association of PTPN22 rs2476601 Polymorphism with Rheumatoid Arthritis and Celiac Disease in Khuzestan Province, Southwestern Iran.rs2476601 polymorphism in PTPN22 is associated with Crohn's disease but not with ulcerative colitis: a meta-analysis of 16,838 cases and 13,356 controls.Genetics of systemic sclerosis: an update.T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man.Review of the risks and benefits of yellow fever vaccination including some new analyses.Autologous regulatory T cells for the treatment of type 1 diabetes.Influence of type 1 diabetes genes on disease progression: similarities and differences between countries.Candidate genes expressed in human islets and their role in the pathogenesis of type 1 diabetes.Understanding the major risk factors in the beginning and the progression of rheumatoid arthritis: current scenario and future prospects.The PTPN22 R263Q polymorphism confers protection against systemic lupus erythematosus and rheumatoid arthritis, while PTPN22 R620W confers susceptibility to Graves' disease in a Mexican population.Thymic Germinal Centers and Corticosteroids in Myasthenia Gravis: an Immunopathological Study in 1035 Cases and a Critical Review.

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P2860

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

http://www.wikidata.org/entity/Q34026657

description

2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2011 թվականի ապրիլին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

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Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

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Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

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type

label

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

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Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

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Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

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prefLabel

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

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Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

@en

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

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J.FEBSLET.2011.04.032

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Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

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Cristina Sanchez-Blanco

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Garth L Burn

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Lena Svensson

http://www.w3.org/2001/XMLSchema#string

Manoj Saini

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P2860

Subcellular localization of intracellular protein tyrosine phosphatases in T cells

The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases

Identification of substrates of human protein-tyrosine phosphatase PTPN22

Identification of a variant form of tyrosine phosphatase LYP

The tyrosine kinase Csk dimerizes through Its SH3 domain

PTPN22 gene regulates natural killer cell proliferation during in vitro expansion

Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant

Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling

Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases

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