The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts.
about
Unraveling DNA helicases. Motif, structure, mechanism and functionEssential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cellsThe requirement of yeast replication origins for pre-replication complex proteins is modulated by transcription.Structure and Mutagenesis Studies of the C-terminal Region of Licensing Factor Cdt1 Enable the Identification of Key Residues for Binding to Replicative Helicase Mcm ProteinsMcm10 mediates the interaction between DNA replication and silencing machineriesMcm7, a subunit of the presumptive MCM helicase, modulates its own expression in conjunction with Mcm1.Biochemical activities associated with mouse Mcm2 proteinRoles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complexInsights into the MCM functional mechanism: lessons learned from the archaeal MCM complex.Origin recognition and the chromosome cycleFunctional cooperation between FACT and MCM is coordinated with cell cycle and differential complex formation.Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progressionThe DNA replication factor MCM5 is essential for Stat1-mediated transcriptional activation.Phosphorylation of Mcm4 at specific sites by cyclin-dependent kinase leads to loss of Mcm4,6,7 helicase activity.The interaction between checkpoint kinase 1 (Chk1) and the minichromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation.Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas.Identification of MCM4 as a target of the DNA replication block checkpoint system.A novel zinc finger is required for Mcm10 homocomplex assembly.mRNA deadenylation by PARN is essential for embryogenesis in higher plantsDifferent phenotypes in vivo are associated with ATPase motif mutations in Schizosaccharomyces pombe minichromosome maintenance proteinsThe PS1 hairpin of Mcm3 is essential for viability and for DNA unwinding in vitro.Analyses of the interaction between the origin binding domain from simian virus 40 T antigen and single-stranded DNA provide insights into DNA unwinding and initiation of DNA replicationInitiation of DNA replication: lessons from viral initiator proteins.Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation.Thermococcus kodakarensis encodes three MCM homologs but only one is essential.Eukaryotic MCM proteins: beyond replication initiation.Coupling of DNA binding and helicase activity is mediated by a conserved loop in the MCM protein.Double hexamer disruption and biochemical activities of Methanobacterium thermoautotrophicum MCM.Essential role of MCM proteins in premeiotic DNA replication.The minichromosome maintenance proteins 2-7 (MCM2-7) are necessary for RNA polymerase II (Pol II)-mediated transcription.ATPase-dependent quality control of DNA replication origin licensing.Conditional expression of MCM7 increases tumor growth without altering DNA replication activity.The cyclin D1-dependent kinase associates with the pre-replication complex and modulates RB.MCM7 binding.The DNA replication checkpoint aids survival of plants deficient in the novel replisome factor ETG1.Modular organization of a Cdc6-like protein from the crenarchaeon Sulfolobus solfataricusInhibition of unwinding and ATPase activities of pea MCM6 DNA helicase by actinomycin and nogalamycin.Mcm3 is polyubiquitinated during mitosis before establishment of the pre-replication complex.Regulation of minichromosome maintenance helicase activity by Cdc6.Biochemical characterization of the Methanothermobacter thermautotrophicus minichromosome maintenance (MCM) helicase N-terminal domains.DNA unwinding is an Mcm complex-dependent and ATP hydrolysis-dependent process.
P2860
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P2860
The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts.
description
2000 nî lūn-bûn
@nan
2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts.
@ast
The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts.
@en
The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts.
@nl
type
label
The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts.
@ast
The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts.
@en
The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts.
@nl
prefLabel
The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts.
@ast
The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts.
@en
The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts.
@nl
P2860
P356
P1476
The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts
@en
P2093
P2860
P304
34833-34836
P356
10.1074/JBC.R000018200
P407
P577
2000-11-01T00:00:00Z