MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. - Wikidata - awgldk - TriplyDB

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.

http://www.wikidata.org/entity/Q34028756

about

5'-Monophosphate-activated protein kinase (AMPK) improves autophagic activity in diabetes and diabetic complications Ongoing controversies surrounding cardiac remodeling: is it black and white-or rather fifty shades of gray?Therapeutic targeting of autophagy: potential and concerns in treating cardiovascular disease Targeting disease through novel pathways of apoptosis and autophagy The two faces of miR-29 Molecular basis of physiological heart growth: fundamental concepts and new players Multifaceted role of insulin-like growth factors and mammalian target of rapamycin in skeletal muscle Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth Autophagy and cardiovascular aging: lesson learned from rapamycin.Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation Anti-remodeling effects of rapamycin in experimental heart failure: dose response and interaction with angiotensin receptor blockade 17ß-Estradiol regulates mTORC2 sensitivity to rapamycin in adaptive cardiac remodeling A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy Nprl3 is required for normal development of the cardiovascular system Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice Insulin Signaling and Heart Failure.Glucose regulation of load-induced mTOR signaling and ER stress in mammalian heart.Titin-truncating variants affect heart function in disease cohorts and the general population.The mTOR inhibitor everolimus in combination with azacitidine in patients with relapsed/refractory acute myeloid leukemia: a phase Ib/II study.Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice.Effect of lithium on ventricular remodelling in infarcted rats via the Akt/mTOR signalling pathways Rag GTPases are cardioprotective by regulating lysosomal function.Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1.Drosophila, genetic screens, and cardiac function Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period.mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy.PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cytoprotection Mechanical stimulation induces mTOR signaling via an ERK-independent mechanism: implications for a direct activation of mTOR by phosphatidic acid.MiR-451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC1.Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit?IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.Three 4-letter words of hypertension-related cardiac hypertrophy: TRPC, mTOR, and HDAC.mTOR regulates brain morphogenesis by mediating GSK3 signaling.New insights into insulin resistance in the diabetic heart.Cardiac insulin resistance and microRNA modulators.MicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis.

P2860

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P2860

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.

http://www.wikidata.org/entity/Q34028756

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.

@ast

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.

@en

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.

@nl

type

label

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.

@ast

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.

@en

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.

@nl

prefLabel

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.

@ast

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.

@en

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.

@nl

P1433

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P1433

Journal of Clinical Investigation

P1476

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.

@en

P2093

Denghong Zhang

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Jianlin Zhang

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Joan Heller Brown

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Ju Chen

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Katherine Huang

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Kirk L Peterson

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Kun-Liang Guan

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Michael V G Latronico

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Nancy D Dalton

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Riccardo Contu

http://www.w3.org/2001/XMLSchema#string

P2860

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease

P304

2805-2816

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scholarly article

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10.1172/JCI43008

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P433

8

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P478

120

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Gianluigi Condorelli

Daniele Catalucci

Nahum Sonenberg

P577

2010-07-19T00:00:00Z

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20644257

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2912201

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