IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. - Wikidata - awgldk - TriplyDB

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

http://www.wikidata.org/entity/Q34836259

about

PI3K and AKT: Unfaithful Partners in Cancer Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity Targeting TBK1 inhibits migration and resistance to MEK inhibitors in mutant NRAS melanoma.PI3K-independent AKT activation in cancers: a treasure trove for novel therapeutics JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic Identification of Akt interaction protein PHF20/TZP that transcriptionally regulates p53 Transforming Big Data into Cancer-Relevant Insight: An Initial, Multi-Tier Approach to Assess Reproducibility and Relevance.Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice.Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling.IKBKE phosphorylation and inhibition of FOXO3a: a mechanism of IKBKE oncogenic function.Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation Pediatric phase II trials of poly-ICLC in the management of newly diagnosed and recurrent brain tumors.TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2 Inhibitor of κB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection Elevated PI3K signaling drives multiple breast cancer subtypes.Proteome from patients with metabolic syndrome is regulated by quantity and quality of dietary lipids.IKBKE Upregulation is Positively Associated with Squamous Cell Carcinoma of the Lung In Vivo and Malignant Transformation of Human Bronchial Epithelial Cells In Vitro.mTOR complex 2 signaling and functions Kinome expression profiling identifies IKBKE as a predictor of overall survival in clear cell renal cell carcinoma patients.Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR).Regulation of IKKε Expression by Akt2 Isoform.Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 The pivotal role of TBK1 in inflammatory responses mediated by macrophages Role of PI3K-AKT-mTOR and Wnt Signaling Pathways in Transition of G1-S Phase of Cell Cycle in Cancer Cells.Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells TBK1 regulates prostate cancer dormancy through mTOR inhibition.Requirement for Rictor in homeostasis and function of mature B lymphoid cells.Structure and ubiquitination-dependent activation of TANK-binding kinase 1.TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation.The inhibitor of kappa B kinase-epsilon regulates MMP-3 expression levels and can promote lung metastasis.Elevated expression of TANK-binding kinase 1 enhances tamoxifen resistance in breast cancer IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response Selective TBK1/IKKi dual inhibitors with anticancer potency.MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation Mammalian target of rapamycin signaling in cardiac physiology and disease.Mammalian TOR signaling to the AGC kinases.

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P2860

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

http://www.wikidata.org/entity/Q34836259

description

2011 nî lūn-bûn

@nan

2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

@ast

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

@en

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

@nl

type

label

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

@ast

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

@en

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

@nl

prefLabel

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

@ast

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

@en

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

@nl

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PNAS.1016132108

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Proceedings of the National Academy of Sciences of the United States of America

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IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation

@en

P2093

Bin Zhao

http://www.w3.org/2001/XMLSchema#string

Cun-Yu Wang

http://www.w3.org/2001/XMLSchema#string

Denghong Zhang

http://www.w3.org/2001/XMLSchema#string

Kun-Liang Guan

http://www.w3.org/2001/XMLSchema#string

Min-Kan Lu

http://www.w3.org/2001/XMLSchema#string

Ming You

http://www.w3.org/2001/XMLSchema#string

Xiaoduo Xie

http://www.w3.org/2001/XMLSchema#string

P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

Mechanism of activation of protein kinase B by insulin and IGF-1

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

The phosphoinositide 3-kinase pathway

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

Regulation and function of IKK and IKK-related kinases

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16

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108

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Gianluigi Condorelli

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2011-04-04T00:00:00Z

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50999570

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phosphorylation

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3081021

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