Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice.
about
The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinityType 1 diabetes: translating mechanistic observations into effective clinical outcomesReconstitution of paired T cell receptor alpha- and beta-chains from microdissected single cells of human inflammatory tissues.Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice.On the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes.A special population of regulatory T cells potentiates muscle repair.Paired analysis of TCRα and TCRβ chains at the single-cell level in mice.Reduction of T cell receptor diversity in NOD mice prevents development of type 1 diabetes but not Sjögren's syndrome.Autoreactive effector/memory CD4+ and CD8+ T cells infiltrating grafted and endogenous islets in diabetic NOD mice exhibit similar T cell receptor usage.Alloreactivity is limited by the endogenous peptide repertoireSelf-pMHCII complexes are variably expressed in the thymus and periphery independent of mRNA expression but dependent on the activation state of the APCsNormalization of obesity-associated insulin resistance through immunotherapyHigh-throughput sequencing of islet-infiltrating memory CD4+ T cells reveals a similar pattern of TCR Vβ usage in prediabetic and diabetic NOD miceSpectratyping analysis of the islet-reactive T cell repertoire in diabetic NOD Igμ(null) mice after polyclonal B cell reconstitutionMouse liver-specific CD8(+) T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes.Prevention of type 1 diabetes in the rat with an allele-specific anti-T-cell receptor antibody: Vβ13 as a therapeutic target and biomarkerCeliac disease and transglutaminase 2: a model for posttranslational modification of antigens and HLA association in the pathogenesis of autoimmune disorders.Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance.Structural determinants of T-cell receptor bias in immunity.The vicious cycle of apoptotic beta-cell death in type 1 diabetes.K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors.Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models.T cell populations in the pancreatic lymph node naturally and consistently expand and contract in NOD mice as disease progresses.CXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic miceMechanisms of diabetic autoimmunity: I--the inductive interface between islets and the immune system at onset of inflammation.The peptide-binding motif of HLA-DR8 shares important structural features with other type 1 diabetes-associated alleles.Rescue of cytotoxic function in the CD8alpha knockout mouse by removal of MHC class II.Alloreactive T cells respond specifically to multiple distinct peptide-MHC complexes.The role of HLA-DQ8 beta57 polymorphism in the anti-gluten T-cell response in coeliac disease.Autoimmune Responses to Exosomes and Candidate Antigens Contribute to Type 1 Diabetes in Non-Obese Diabetic Mice.CD40-mediated signalling influences trafficking, T-cell receptor expression, and T-cell pathogenesis, in the NOD model of type 1 diabetes.Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR.Recent insights into CD4+T-cell specificity and function in Type 1 diabetesExpanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
P2860
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P2860
Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Restricted islet-cell reactive ...... islet infiltrates in NOD mice.
@ast
Restricted islet-cell reactive ...... islet infiltrates in NOD mice.
@en
Restricted islet-cell reactive ...... islet infiltrates in NOD mice.
@nl
type
label
Restricted islet-cell reactive ...... islet infiltrates in NOD mice.
@ast
Restricted islet-cell reactive ...... islet infiltrates in NOD mice.
@en
Restricted islet-cell reactive ...... islet infiltrates in NOD mice.
@nl
prefLabel
Restricted islet-cell reactive ...... islet infiltrates in NOD mice.
@ast
Restricted islet-cell reactive ...... islet infiltrates in NOD mice.
@en
Restricted islet-cell reactive ...... islet infiltrates in NOD mice.
@nl
P2093
P2860
P356
P1476
Restricted islet-cell reactive ...... islet infiltrates in NOD mice.
@en
P2093
Felix J Baker
Mark M Davis
Yueh-hsiu Chien
P2860
P304
P356
10.1073/PNAS.142284899
P407
P577
2002-06-24T00:00:00Z