Transgenic parasites stably expressing full-length Plasmodium falciparum circumsporozoite protein as a model for vaccine down-selection in mice using sterile protection as an endpoint. - Wikidata - awgldk - TriplyDB

Transgenic parasites stably expressing full-length Plasmodium falciparum circumsporozoite protein as a model for vaccine down-selection in mice using sterile protection as an endpoint.

Transgenic parasites stably expressing full-length Plasmodium falciparum circumsporozoite protein as a model for vaccine down-selection in mice using sterile protection as an endpoint.

http://www.wikidata.org/entity/Q34036184

about

Malaria vaccines: identifying Plasmodium falciparum liver-stage targets IgG2 antibodies against a clinical grade Plasmodium falciparum CSP vaccine antigen associate with protection against transgenic sporozoite challenge in mice.The effect of immunization schedule with the malaria vaccine candidate RTS,S/AS01E on protective efficacy and anti-circumsporozoite protein antibody avidity in African infants P. falciparum and P. vivax Epitope-Focused VLPs Elicit Sterile Immunity to Blood Stage Infections.Head-to-Head Comparison of Soluble vs. Qβ VLP Circumsporozoite Protein Vaccines Reveals Selective Enhancement of NANP Repeat Responses.A Plasmodium Promiscuous T Cell Epitope Delivered within the Ad5 Hexon Protein Enhances the Protective Efficacy of a Protein Based Malaria Vaccine Seroprevalence of Antibodies against Plasmodium falciparum Sporozoite Antigens as Predictive Disease Transmission Markers in an Area of Ghana with Seasonal Malaria Transmission.Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort A highly infectious Plasmodium yoelii parasite, bearing Plasmodium falciparum circumsporozoite protein.Development of a Plasmodium berghei transgenic parasite expressing the full-length Plasmodium vivax circumsporozoite VK247 protein for testing vaccine efficacy in a murine model Rhesus macaque and mouse models for down-selecting circumsporozoite protein based malaria vaccines differ significantly in immunogenicity and functional outcomes Anti-sporozoite antibodies as alternative markers for malaria transmission intensity estimation.The biological function of antibodies induced by the RTS,S/AS01 malaria vaccine candidate is determined by their fine specificity Human CD8+ T cells mediate protective immunity induced by a human malaria vaccine in human immune system mice.Delayed fractional dose regimen of the RTS,S/AS01 malaria vaccine candidate enhances an IgG4 response that inhibits serum opsonophagocytosis.A prime-boost immunization regimen based on a simian adenovirus 36 vectored multi-stage malaria vaccine induces protective immunity in mice.Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity.Novel ELISA method as exploratory tool to assess immunity induced by radiated attenuated sporozoites to decipher protective immunity.Assessment of the quality and quantity of naturally induced antibody responses to EBA175RIII-V in Ghanaian children living in two communities with varying malaria transmission patterns.

P2860

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P2860

Transgenic parasites stably expressing full-length Plasmodium falciparum circumsporozoite protein as a model for vaccine down-selection in mice using sterile protection as an endpoint.

http://www.wikidata.org/entity/Q34036184

description

2013 nî lūn-bûn

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2013 թվականի մարտին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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Transgenic parasites stably ex ...... ile protection as an endpoint.

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Transgenic parasites stably ex ...... ile protection as an endpoint.

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Transgenic parasites stably ex ...... ile protection as an endpoint.

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Transgenic parasites stably ex ...... ile protection as an endpoint.

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Transgenic parasites stably ex ...... ile protection as an endpoint.

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Transgenic parasites stably ex ...... ile protection as an endpoint.

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Clinical and Vaccine Immunology

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Transgenic parasites stably ex ...... ile protection as an endpoint.

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P2093

Brooke Bozick

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Christian F Ockenhouse

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Christopher D Pool

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Clara Brando

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Divya Angra

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Jason W Bennett

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Jennifer Nicki

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Jittawadee R Murphy

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Margot DeBot

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Michael D Porter

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P2860

Unexpected fold in the circumsporozoite protein target of malaria vaccines

Function of region I and II adhesive motifs of Plasmodium falciparum circumsporozoite protein in sporozoite motility and infectivity

The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion.

Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum.

Roles of the amino terminal region and repeat region of the Plasmodium berghei circumsporozoite protein in parasite infectivity

Inhibition of entry of Plasmodium falciparum and P. vivax sporozoites into cultured cells; an in vitro assay of protective antibodies.

Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection.

Direct microscopic quantification of dynamics of Plasmodium berghei sporozoite transmission from mosquitoes to mice.

Protective antibody and CD8+ T-cell responses to the Plasmodium falciparum circumsporozoite protein induced by a nanoparticle vaccine

Full-length Plasmodium falciparum circumsporozoite protein administered with long-chain poly(I·C) or the Toll-like receptor 4 agonist glucopyranosyl lipid adjuvant-stable emulsion elicits potent antibody and CD4+ T cell immunity and protection in mi

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803-810

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scholarly article

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10.1128/CVI.00066-13

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6

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20

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Andrea Crisanti

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2013-03-27T00:00:00Z

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236088155

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23536694

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Plasmodium falciparum

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3675977

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