Necroptosis drives motor neuron death in models of both sporadic and familial ALS. - Wikidata - awgldk - TriplyDB

Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

http://www.wikidata.org/entity/Q34039826

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Post-translational modifications as key regulators of TNF-induced necroptosis An outline of necrosome triggers Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration Neuroinflammation in motor neuron disease iPSC-Based Models to Unravel Key Pathogenetic Processes Underlying Motor Neuron Disease Development Induced pluripotent stem cells from ALS patients for disease modeling Role of necroptosis in the pathogenesis of solid organ injury A perspective on stem cell modeling of amyotrophic lateral sclerosis A comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis.The neuron-astrocyte-microglia triad in a rat model of chronic cerebral hypoperfusion: protective effect of dipyridamole.Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis.Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants.Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo.Human glial progenitor engraftment and gene expression is independent of the ALS environment RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.Formation and spreading of TDP-43 aggregates in cultured neuronal and glial cells demonstrated by time-lapse imaging.Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons Necroptosis mediates TNF-induced toxicity of hippocampal neurons.Calcium-Sensing Receptors of Human Astrocyte-Neuron Teams: Amyloid-β-Driven Mediators and Therapeutic Targets of Alzheimer's Disease TDP-43 toxicity proceeds via calcium dysregulation and necrosis in aging Caenorhabditis elegans motor neurons.Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex Spinal muscular atrophy: from tissue specificity to therapeutic strategies Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1.Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling Upregulation of the receptor-interacting protein 3 expression and involvement in neural tissue damage after spinal cord injury in mice.Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis.Wnt Signaling Alteration in the Spinal Cord of Amyotrophic Lateral Sclerosis Transgenic Mice: Special Focus on Frizzled-5 Cellular Expression Pattern MicroNeurotrophins Improve Survival in Motor Neuron-Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis.The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis.Stem cell therapy for amyotrophic lateral sclerosis CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis.Prospects for engineering neurons from local neocortical cell populations as cell-mediated therapy for neurological disorders Therapeutic rAAVrh10 Mediated SOD1 Silencing in Adult SOD1(G93A) Mice and Nonhuman Primates.HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death.Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis.Necroptosis in Niemann-Pick disease, type C1: a potential therapeutic target.ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways.

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Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

http://www.wikidata.org/entity/Q34039826

description

2014 nî lūn-bûn

@nan

2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

@ast

Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

@en

Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

@nl

type

label

Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

@ast

Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

@en

Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

@nl

prefLabel

Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

@ast

Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

@en

Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

@nl

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J.NEURON.2014.01.011

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Necroptosis drives motor neuron death in models of both sporadic and familial ALS

@en

P2093

Changhao Yu

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Christopher E Henderson

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Dimitra Papadimitriou

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Hynek Wichterle

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Kristin A Politi

http://www.w3.org/2001/XMLSchema#string

Lucas Hoffmann

http://www.w3.org/2001/XMLSchema#string

Martijn Koolen

http://www.w3.org/2001/XMLSchema#string

Peter Nagy

http://www.w3.org/2001/XMLSchema#string

Serge Przedborski

http://www.w3.org/2001/XMLSchema#string

Shingo Kariya

http://www.w3.org/2001/XMLSchema#string

P2860

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX

Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

Identification of RIP1 kinase as a specific cellular target of necrostatins

Directed differentiation of embryonic stem cells into motor neurons

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

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1001-1008

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10.1016/J.NEURON.2014.01.011

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5

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81

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Mackenzie Mathis

Hiroshi Mitsumoto

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2014-02-06T00:00:00Z

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260129843

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24508385

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amyotrophic lateral sclerosis

P932

3951532

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