Spinal muscular atrophy: from tissue specificity to therapeutic strategies

Spinal muscular atrophy: from tissue specificity to therapeutic strategies

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http://www.wikidata.org/entity/Q35029616
Is spinal muscular atrophy a disease of the motor neurons only: pathogenesis and therapeutic implications?LNA/DNA mixmer-based antisense oligonucleotides correct alternative splicing of the SMN2 gene and restore SMN protein expression in type 1 SMA fibroblastsSMN expression is required in motor neurons to rescue electrophysiological deficits in the SMNΔ7 mouse model of SMA.SAM68 is a physiological regulator of SMN2 splicing in spinal muscular atrophy.Systemic, postsymptomatic antisense oligonucleotide rescues motor unit maturation delay in a new mouse model for type II/III spinal muscular atrophy.Chronic Treatment with the AMPK Agonist AICAR Prevents Skeletal Muscle Pathology but Fails to Improve Clinical Outcome in a Mouse Model of Severe Spinal Muscular Atrophy.ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in miceNeuroprotective Effect of Non-viral Gene Therapy Treatment Based on Tetanus Toxin C-fragment in a Severe Mouse Model of Spinal Muscular AtrophyPharmacologically induced mouse model of adult spinal muscular atrophy to evaluate effectiveness of therapeutics after disease onset.An open source tool for automatic spatiotemporal assessment of calcium transients and local 'signal-close-to-noise' activity in calcium imaging data.Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes
P2860

Spinal muscular atrophy: from tissue specificity to therapeutic strategies

Item
http://www.wikidata.org/entity/Q35029616
description
2015 nî lūn-bûn
@nan
2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Spinal muscular atrophy: from tissue specificity to therapeutic strategies
@ast
Spinal muscular atrophy: from tissue specificity to therapeutic strategies
@en
type
label
Spinal muscular atrophy: from tissue specificity to therapeutic strategies
@ast
Spinal muscular atrophy: from tissue specificity to therapeutic strategies
@en
prefLabel
Spinal muscular atrophy: from tissue specificity to therapeutic strategies
@ast
Spinal muscular atrophy: from tissue specificity to therapeutic strategies
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P478
P50
P577
P698
P921
P932
P356
P1433
P1476
Spinal muscular atrophy: from tissue specificity to therapeutic strategies
@en
P2093
P2860
P304
P31
P356
P478
P50
P577
P698
P921
P932