Novel Kv7.1-phosphatidylinositol 4,5-bisphosphate interaction sites uncovered by charge neutralization scanning
about
Regulation of KCNQ/Kv7 family voltage-gated K+ channels by lipids.Structural interplay of KV7.1 and KCNE1 is essential for normal repolarization and is compromised in short QT syndrome 2 (KV7.1-A287T).PIP₂-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6.Probing binding sites and mechanisms of action of an I(Ks) activator by computations and experiments.Voltage-Dependent Gating: Novel Insights from KCNQ1 Channels.Modulation of Kv7 channels and excitability in the brain.Competition of calcified calmodulin N lobe and PIP2 to an LQT mutation site in Kv7.1 channel.Ca(2+)-Calmodulin and PIP2 interactions at the proximal C-terminus of Kv7 channels.Phosphatidylinositol 4,5-bisphosphate (PIP2 ) modulates afterhyperpolarizations in oxytocin neurons of the supraoptic nucleus.Studying Kv Channels Function using Computational Methods.
P2860
Q30394930-E73F9DCA-0A4E-4F12-8269-B62ADCB5911AQ33644389-58C3BC43-75C7-4956-8B97-B91726D576CBQ34830254-50D4736A-A2B7-4D56-A494-DCA4244B905BQ34862841-D2A740FA-E02B-40A3-A8DF-094BCF2B07ACQ38690407-A9844295-7C3E-46CF-BD66-F366BFFEE6C8Q38958968-16F760F3-85A2-413F-8622-CE678093C5F9Q39016123-2C33E655-98D0-40CA-BB58-DFAB7C030519Q42694899-385C2F83-C909-48AC-8184-BD9D1418766EQ47801931-E0E89338-0A50-4370-9C04-4F6482B1C696Q50067406-C4F593EB-1A3A-4BE8-9A37-D7FADDE42E45
P2860
Novel Kv7.1-phosphatidylinositol 4,5-bisphosphate interaction sites uncovered by charge neutralization scanning
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Novel Kv7.1-phosphatidylinosit ...... charge neutralization scanning
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Novel Kv7.1-phosphatidylinosit ...... charge neutralization scanning
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Novel Kv7.1-phosphatidylinosit ...... charge neutralization scanning
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Novel Kv7.1-phosphatidylinosit ...... charge neutralization scanning
@ast
Novel Kv7.1-phosphatidylinosit ...... charge neutralization scanning
@en
Novel Kv7.1-phosphatidylinosit ...... charge neutralization scanning
@nl
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Novel Kv7.1-phosphatidylinosit ...... charge neutralization scanning
@ast
Novel Kv7.1-phosphatidylinosit ...... charge neutralization scanning
@en
Novel Kv7.1-phosphatidylinosit ...... charge neutralization scanning
@nl
P2093
P2860
P356
P1476
Novel Kv7.1-phosphatidylinosit ...... charge neutralization scanning
@en
P2093
Eva Wrobel
Guiscard Seebohm
Karina Eckey
Nathalie Strutz-Seebohm
P2860
P304
22749-22758
P356
10.1074/JBC.M114.589796
P407
P577
2014-06-19T00:00:00Z