The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.

The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.

Item
http://www.wikidata.org/entity/Q34045809
Interaction of p53 with its consensus DNA-binding siteIdentification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complexAugmented DNA-binding activity of p53 protein encoded by a carboxyl-terminal alternatively spliced mRNA is blocked by p53 protein encoded by the regularly spliced form.High metastatic potential in mice inheriting a targeted p53 missense mutation.p53 domains: structure, oligomerization, and transformation.Hot-spot p53 mutants interact specifically with two cellular proteins during progression of the cell cycle.A meanfield approach to the thermodynamics of a protein-solvent system with application to the oligomerization of the tumor suppressor p53Mutation of the endogenous p53 gene in cells transformed by HPV-16 E7 and EJ c-ras confers a growth advantage involving an autocrine mechanism.p53 suppresses CCL2-induced subcutaneous tumor xenograft.p53 is an important regulator of CCL2 gene expression.Different regulation of the p53 core domain activities 3'-to-5' exonuclease and sequence-specific DNA bindingActivation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain.Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation.The murine C'-terminally alternatively spliced form of p53 induces attenuated apoptosis in myeloid cells.Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.Comparison of p53 gene mutation and protein overexpression in colorectal carcinomas
P2860

The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.

Item
http://www.wikidata.org/entity/Q34045809
description
1993 nî lūn-bûn
@nan
1993 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի մարտին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
The transforming and suppresso ...... ion and nuclear translocation.
@ast
The transforming and suppresso ...... ion and nuclear translocation.
@en
The transforming and suppresso ...... ion and nuclear translocation.
@nl
type
label
The transforming and suppresso ...... ion and nuclear translocation.
@ast
The transforming and suppresso ...... ion and nuclear translocation.
@en
The transforming and suppresso ...... ion and nuclear translocation.
@nl
prefLabel
The transforming and suppresso ...... ion and nuclear translocation.
@ast
The transforming and suppresso ...... ion and nuclear translocation.
@en
The transforming and suppresso ...... ion and nuclear translocation.
@nl
P1433
P1476
P2093
P2860
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The transforming and suppresso ...... tion and nuclear translocation
@en
P2093
P2860
P304
P31
P356
10.1002/J.1460-2075.1993.TB05744.X
P407
P433
P478
P577
P698
P921
P932