Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic beta-cells.
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High glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 β-cells by increasing the posttranslational carboxylmethylation of its catalytic subunitPhagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: evidence for regulation by Rac1.Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation.Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approachesIsoprenylcysteine carboxyl methyltransferase facilitates glucose-induced Rac1 activation, ROS generation and insulin secretion in INS 832/13 β-cells.Protein histidine [de]phosphorylation in insulin secretion: abnormalities in models of impaired insulin secretion.Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet.Lipotoxicity augments glucotoxicity-induced mitochondrial damage in the development of diabetic retinopathyTiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein PalmitoylationUpregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic beta-cells: attenuation of oxidative and nitrosative stress by 2-bromopalmitate.NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents.The role of thioredoxin 1 in the mycophenolic acid-induced apoptosis of insulin-producing cellsDeoxysphingolipids: β-cell, beware of these new kids on the block.Ceramide formation as a target in beta-cell survival and function.Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes.Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 (Rac1)-mediated activation of p53 and ATM kinase in pancreatic β-cells.Tiam1/Vav2-Rac1 axis: A tug-of-war between islet function and dysfunction.Activation of apocynin-sensitive NADPH oxidase (Nox2) activity in INS-1 832/13 cells under glucotoxic conditions.L- threo -C6-pyridinium-ceramide bromide, a novel cationic ceramide, induces NADPH oxidase activation, mitochondrial dysfunction and loss in cell viability in INS 832/13 β-cells.Hyperlipidemia and the development of diabetic retinopathy: Comparison between type 1 and type 2 animal models.Overexpression of glutathione peroxidase 4 prevents β-cell dysfunction induced by prolonged elevation of lipids in vivo.Glucotoxicity promotes aberrant activation and mislocalization of Ras-related C3 botulinum toxin substrate 1 [Rac1] and metabolic dysfunction in pancreatic islet β-cells: reversal of such metabolic defects by metformin.Evidence for the involvement of GPR40 and NADPH oxidase in palmitic acid-induced superoxide production and insulin secretion.The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice.TIAM1-RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy.Role of G-proteins in islet function in health and diabetes.Postprandial triglyceride-rich lipoproteins promote invasion of human coronary artery smooth muscle cells in a fatty-acid manner through PI3k-Rac1-JNK signaling.
P2860
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P2860
Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic beta-cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年学术文章
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2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
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name
Tiam1/Rac1 signaling pathway m ...... tial in pancreatic beta-cells.
@ast
Tiam1/Rac1 signaling pathway m ...... tial in pancreatic beta-cells.
@en
Tiam1/Rac1 signaling pathway m ...... tial in pancreatic beta-cells.
@nl
type
label
Tiam1/Rac1 signaling pathway m ...... tial in pancreatic beta-cells.
@ast
Tiam1/Rac1 signaling pathway m ...... tial in pancreatic beta-cells.
@en
Tiam1/Rac1 signaling pathway m ...... tial in pancreatic beta-cells.
@nl
prefLabel
Tiam1/Rac1 signaling pathway m ...... tial in pancreatic beta-cells.
@ast
Tiam1/Rac1 signaling pathway m ...... tial in pancreatic beta-cells.
@en
Tiam1/Rac1 signaling pathway m ...... tial in pancreatic beta-cells.
@nl
P2860
P1476
Tiam1/Rac1 signaling pathway m ...... ntial in pancreatic beta-cells
@en
P2093
Bhavaani Jayaram
Wasanthi Subasinghe
P2860
P304
P356
10.1016/J.BCP.2010.05.006
P407
P577
2010-05-21T00:00:00Z