Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet.
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High glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 β-cells by increasing the posttranslational carboxylmethylation of its catalytic subunitGlucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cellsHow the location of superoxide generation influences the β-cell response to nitric oxide.EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic β-cells.Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein PalmitoylationPathway-Based Genome-wide Association Studies Reveal That the Rac1 Pathway Is Associated with Plasma Adiponectin Levels.NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion.Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic beta-cells: attenuation of oxidative and nitrosative stress by 2-bromopalmitate.A lack of 'glue' misplaces Rab27A to cause islet dysfunction in diabetesCardiomyocyte-specific overexpression of an active form of Rac predisposes the heart to increased myocardial stunning and ischemia-reperfusion injuryAlterations in glutathione redox metabolism, oxidative stress, and mitochondrial function in the left ventricle of elderly Zucker diabetic fatty rat heart.Regulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy.Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular diseaseHigh glucose activates the alternative ACE2/Ang-(1-7)/Mas and APN/Ang IV/IRAP RAS axes in pancreatic β-cells.Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic β-cells: protection by nifedipine.Do β-cells generate peroxynitrite in response to cytokine treatment?Association between statins and infections among patients with diabetes: a cohort and prescription sequence symmetry analysisInhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes.Deoxysphingolipids: β-cell, beware of these new kids on the block.Oxidative stress, Nox isoforms and complications of diabetes--potential targets for novel therapies.Role of oxidative stress and Ca²⁺ signaling on molecular pathways of neuropathic pain in diabetes: focus on TRP channels.TRPM2-mediated rise in mitochondrial Zn(2+) promotes palmitate-induced mitochondrial fission and pancreatic β-cell death in rodents.Omega-3 fatty acids control productions of superoxide and nitrogen oxide and insulin content in INS-1E cells.Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 (Rac1)-mediated activation of p53 and ATM kinase in pancreatic β-cells.Epigenetic regulation of redox signaling in diabetic retinopathy: Role of Nrf2.Tiam1/Vav2-Rac1 axis: A tug-of-war between islet function and dysfunction.Activation of apocynin-sensitive NADPH oxidase (Nox2) activity in INS-1 832/13 cells under glucotoxic conditions.L- threo -C6-pyridinium-ceramide bromide, a novel cationic ceramide, induces NADPH oxidase activation, mitochondrial dysfunction and loss in cell viability in INS 832/13 β-cells.NOX, NOX Who is There? The Contribution of NADPH Oxidase One to Beta Cell Dysfunction.Is Heterogeneity in the Effects of Statins on Infection Outcomes across Clinical Studies Due to Bias?Manganese supplementation increases adiponectin and lowers ICAM-1 and creatinine blood levels in Zucker type 2 diabetic rats, and downregulates ICAM-1 by upregulating adiponectin multimerization protein (DsbA-L) in endothelial cells.Salidroside, A Natural Antioxidant, Improves β-Cell Survival and Function via Activating AMPK Pathway.Glucotoxicity promotes aberrant activation and mislocalization of Ras-related C3 botulinum toxin substrate 1 [Rac1] and metabolic dysfunction in pancreatic islet β-cells: reversal of such metabolic defects by metformin.The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice.Generation of oxyradicals (O2. and H2O2), mitochondrial activity and induction of apoptosis of PBMC of Cyprinus carpio carpio treated in vivo with halomethanes and with recombinant HSP60 kDa and with LPS of Klebsiella pneumoniae.TIAM1-RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy.Role of G-proteins in islet function in health and diabetes.The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing.Melatonin nephroprotective action in Zucker diabetic fatty rats involves its inhibitory effect on NADPH oxidase.The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro
P2860
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P2860
Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet.
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Increased phagocyte-like NADPH ...... ulation in the diabetic islet.
@ast
Increased phagocyte-like NADPH ...... ulation in the diabetic islet.
@en
type
label
Increased phagocyte-like NADPH ...... ulation in the diabetic islet.
@ast
Increased phagocyte-like NADPH ...... ulation in the diabetic islet.
@en
prefLabel
Increased phagocyte-like NADPH ...... ulation in the diabetic islet.
@ast
Increased phagocyte-like NADPH ...... ulation in the diabetic islet.
@en
P2093
P2860
P356
P1433
P1476
Increased phagocyte-like NADPH ...... ulation in the diabetic islet.
@en
P2093
Anjaneyulu Kowluru
Bhavaani Jayaram
Chandrashekara N Kyathanahalli
Christopher J Rhodes
Ismail Syed
Renu A Kowluru
Sudha Govind
P2860
P304
P356
10.2337/DB11-0809
P407
P577
2011-09-12T00:00:00Z