Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications. - Wikidata - awgldk - TriplyDB

Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.

Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.

http://www.wikidata.org/entity/Q34072984

about

Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporter Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia.New hopes from old drugs: revisiting DNA-binding small molecules as anticancer agents.Curaxins: a new family of non-genotoxic multitargeted anticancer agents.Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer.The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death.Small-molecule xenomycins inhibit all stages of the Plasmodium life cycle Recent progress in targeting cancer.NCI's provocative questions on cancer: some answers to ignite discussion.Engagement of Components of DNA-Break Repair Complex and NFκB in Hsp70A1A Transcription Upregulation by Heat Shock.A Novel Function of Molecular Chaperone HSP70: SUPPRESSION OF ONCOGENIC FOXM1 AFTER PROTEOTOXIC STRESS Implication of heat shock factors in tumorigenesis: therapeutical potential.Azadiradione ameliorates polyglutamine expansion disease in Drosophila by potentiating DNA binding activity of heat shock factor 1.Quinacrine induces apoptosis in cancer cells by forming a functional bridge between TRAIL-DR5 complex and modulating the mitochondrial intrinsic cascade.Emergence and natural selection of drug-resistant prions.Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part I.Acridine and acridinones: old and new structures with antimalarial activity.Initial testing (stage 1) of the curaxin CBL0137 by the pediatric preclinical testing program.Targeting HSF1 sensitizes cancer cells to HSP90 inhibition.Parasites and cancers: parasite antigens as possible targets for cancer immunotherapy.Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity.Proteotoxic stress targeted therapy (PSTT): induction of protein misfolding enhances the antitumor effect of the proteasome inhibitor bortezomib.The anticancer drug AUY922 generates a proteomics fingerprint that is highly conserved among structurally diverse Hsp90 inhibitors.Proteotoxic stress targeted therapy (PSTT).Heat shock proteins and cancer therapy: the trail grows hotter!Preclinical Validation of a Single-Treatment Infusion Modality That Can Eradicate Extremity Melanomas.Inhibition of Kir4.1 potassium channels by quinacrine.Vorinostat and quinacrine have synergistic effects in T-cell acute lymphoblastic leukemia through reactive oxygen species increase and mitophagy inhibition.

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P2860

Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.

http://www.wikidata.org/entity/Q34072984

description

2009 nî lūn-bûn

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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

@zh-hk

2009年論文

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2009年論文

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2009年论文

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name

Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.

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Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.

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Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.

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type

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Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.

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Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.

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Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.

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Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.

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Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.

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Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.

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Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.

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Alexander V Gasparian

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Alexandru Almasan

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Amiya K Banerjee

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Andrei P Komarov

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Andrei V Gudkov

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Anton V Gorbachev

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Katerina V Gurova

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Lubov Neznanova

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Nickolay Neznanov

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Robert L Fairchild

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P2860

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

The ubiquitin-proteasome system and its role in inflammatory and autoimmune diseases

Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation.

The heat-shock response

Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors.

Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors.

Systems analysis of chaperone networks in the malarial parasite Plasmodium falciparum.

Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication.

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3960-3970

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10.4161/CC.8.23.10179

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23

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8

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19901558

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