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Glucocerebrosidase is shaking up the synucleinopathiesGaucher disease and comorbidities: B-cell malignancy and parkinsonismIs the bovine lysosomal phospholipase B-like protein an amidase?The relationship between glucocerebrosidase mutations and Parkinson diseaseAmbroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cellsGlucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease.Predicting parkinsonism: new opportunities from Gaucher disease.Detecting non-allelic homologous recombination from high-throughput sequencing data.Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosisBlood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.Comparison of Parkinson risk in Ashkenazi Jewish patients with Gaucher disease and GBA heterozygotes.Emerging insights into the mechanistic link between α-synuclein and glucocerebrosidase in Parkinson's diseaseGaucher disease and its treatment options.Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.Structural features of membrane-bound glucocerebrosidase and α-synuclein probed by neutron reflectometry and fluorescence spectroscopy.The neurogenetics of atypical parkinsonian disordersDifferential effects of severe vs mild GBA mutations on Parkinson disease.Progressive decline of glucocerebrosidase in aging and Parkinson's disease.Gaucher-Associated Parkinsonism.Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity.AMP-activated Protein Kinase Suppresses Biosynthesis of Glucosylceramide by Reducing Intracellular Sugar Nucleotides.Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration.Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice.Glucocerebrosidase activity in Parkinson's disease with and without GBA mutationsProgression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease.Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregatesLipid profiling of parkin-mutant human skin fibroblasts.Parkinsonism syndrome in heterozygotes for Niemann-Pick C1.Pathogenesis, Emerging therapeutic targets and Treatment in Sialidosis.Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathiesMethyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis.Thinking laterally about neurodegenerative proteinopathies.Age- and brain region-dependent α-synuclein oligomerization is attributed to alterations in intrinsic enzymes regulating α-synuclein phosphorylation in aging monkey brains.Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disordersA review of quality of life after predictive testing for and earlier identification of neurodegenerative diseases.A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies.Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease.Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice.Chaperoning glucocerebrosidase: a therapeutic strategy for both Gaucher disease and ParkinsonismDiscovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
The link between the GBA gene and parkinsonism
@ast
The link between the GBA gene and parkinsonism
@en
The link between the GBA gene and parkinsonism
@nl
type
label
The link between the GBA gene and parkinsonism
@ast
The link between the GBA gene and parkinsonism
@en
The link between the GBA gene and parkinsonism
@nl
prefLabel
The link between the GBA gene and parkinsonism
@ast
The link between the GBA gene and parkinsonism
@en
The link between the GBA gene and parkinsonism
@nl
P2860
P1433
P1476
The link between the GBA gene and parkinsonism
@en
P2093
Ellen Sidransky
Grisel Lopez
P2860
P304
P356
10.1016/S1474-4422(12)70190-4
P577
2012-11-01T00:00:00Z