Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation - Wikidata - awgldk - TriplyDB

Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation

Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation

http://www.wikidata.org/entity/Q34081815

about

Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling Early embryonic death in mice lacking the beta-catenin-binding protein Duplin Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis P53 and beta-catenin activity during estrogen treatment of osteoblasts Mammalian target of rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/β-catenin and PTEN Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2 Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis Adenomatous polyposis coli (APC)-independent regulation of beta-catenin degradation via a retinoid X receptor-mediated pathway.Wnt expression and canonical Wnt signaling in human bone marrow B lymphopoiesis Association of p53 Arg72Pro polymorphism and beta-catenin accumulation in mycosis fungoides.MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways Pygo2 regulates β-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through the DNA damage response and the p53/p21 pathway.Increased expression of prothymosin-α, independently or combined with TP53, correlates with poor prognosis in colorectal cancer The cadherin-catenin adhesion system in signaling and cancer.Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection.Normal p53 function in primary cells deficient for Siah genes.Immunohistochemical investigation of cell cycle and apoptosis regulators (survivin, β-catenin, p53, caspase 3) in canine appendicular osteosarcoma.Complete deletion of Apc results in severe polyposis in mice.The role of calcium-binding proteins in the control of transcription: structure to function.Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis.Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during squamous differentiation of endometrial carcinoma cells.Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.A rapid and scalable system for studying gene function in mice using conditional RNA interference.Regulation of lymphoid and myeloid leukemic cell survival: role of stromal cell adhesion molecules.Novel ARF/p53-independent senescence pathways in cancer repression.Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF.Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis The Regulation of Multiple p53 Stress Responses is Mediated through MDM2 Prognostic significance of survivin, β-catenin and p53 expression in urothelial carcinoma.Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo.Molecular basis for the tissue specificity of β-catenin oncogenesis.Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts Molecular networks in microarray analysis.Versatile functions of p53 protein in multicellular organisms Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling The THO ribonucleoprotein complex is required for stem cell homeostasis in the adult mouse small intestine β-Catenin C-terminal signals suppress p53 and are essential for artery formation.Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug.Enhanced endothelial cell senescence by lithium-induced matrix metalloproteinase-1 expression.

P2860

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P2860

Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation

http://www.wikidata.org/entity/Q34081815

description

2001 nî lūn-bûn

@nan

2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

@zh-hant

2001年論文

@zh-hk

2001年論文

@zh-mo

2001年論文

@zh-tw

2001年论文

@wuu

name

Deregulated beta-catenin induc ...... tes with Ras in transformation

@ast

Deregulated beta-catenin induc ...... tes with Ras in transformation

@en

Deregulated beta-catenin induc ...... tes with Ras in transformation

@nl

type

label

Deregulated beta-catenin induc ...... tes with Ras in transformation

@ast

Deregulated beta-catenin induc ...... tes with Ras in transformation

@en

Deregulated beta-catenin induc ...... tes with Ras in transformation

@nl

prefLabel

Deregulated beta-catenin induc ...... tes with Ras in transformation

@ast

Deregulated beta-catenin induc ...... tes with Ras in transformation

@en

Deregulated beta-catenin induc ...... tes with Ras in transformation

@nl

P1433

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P2860

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P932

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P356

P1433

The EMBO Journal

P1476

Deregulated beta-catenin induc ...... tes with Ras in transformation

@en

P2093

A Damalas

http://www.w3.org/2001/XMLSchema#string

M Oren

http://www.w3.org/2001/XMLSchema#string

M Shtutman

http://www.w3.org/2001/XMLSchema#string

S Kahan

http://www.w3.org/2001/XMLSchema#string

P2860

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

Identification of a cryptic nucleolar-localization signal in MDM2

Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin

Identification of c-MYC as a target of the APC pathway

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

p53-independent functions of the p19(ARF) tumor suppressor

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

P304

4912-4922

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scholarly article

P356

10.1093/EMBOJ/20.17.4912

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P407

P433

17

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P478

20

http://www.w3.org/2001/XMLSchema#string

P50

P577

2001-09-01T00:00:00Z

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P5875

11813214

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P698

11532955

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P932

125598

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