Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir.
about
Unique Flap Conformation in an HIV-1 Protease with High-Level Darunavir Resistance.Highly resistant HIV-1 proteases and strategies for their inhibition.HIV-1 Protease Dimerization Dynamics Reveals a Transient Druggable Binding Pocket at the Interface.Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray StudiesC-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including DarunavirElucidating the druggable interface of protein-protein interactions using fragment docking and coevolutionary analysis.Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDSA novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency.Design of Highly Potent, Dual Acting and Central Nervous System Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants.Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance.Inhibition of the precursor and mature forms of HIV-1 protease as a tool for drug evaluation.
P2860
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P2860
Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir.
description
2014 nî lūn-bûn
@nan
2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Dimerization of HIV-1 protease ...... ation inhibition by darunavir.
@ast
Dimerization of HIV-1 protease ...... ation inhibition by darunavir.
@en
Dimerization of HIV-1 protease ...... ation inhibition by darunavir.
@nl
type
label
Dimerization of HIV-1 protease ...... ation inhibition by darunavir.
@ast
Dimerization of HIV-1 protease ...... ation inhibition by darunavir.
@en
Dimerization of HIV-1 protease ...... ation inhibition by darunavir.
@nl
prefLabel
Dimerization of HIV-1 protease ...... ation inhibition by darunavir.
@ast
Dimerization of HIV-1 protease ...... ation inhibition by darunavir.
@en
Dimerization of HIV-1 protease ...... ation inhibition by darunavir.
@nl
P2093
P2860
P356
P1476
Dimerization of HIV-1 protease ...... ation inhibition by darunavir.
@en
P2093
Arun K Ghosh
Debananda Das
Hiroaki Mitsuya
Hironori Hayashi
Manabu Aoki
Nobutoki Takamune
Shogo Misumi
Takashi Nirasawa
Yasuhiro Koh
Yoshihiko Morishita
P2860
P304
12234-12239
P356
10.1073/PNAS.1400027111
P407
P577
2014-08-04T00:00:00Z