about
Persulfides: current knowledge and challenges in chemistry and chemical biologyC-S bond cleavage by a polyketide synthase domain.Characterization of DNA damage induced by a natural product antitumor antibiotic leinamycin in human cancer cells.Entering the leinamycin rearrangement via 2-(trimethylsilyl)ethyl sulfoxidesLeinamycin E1 acting as an anticancer prodrug activated by reactive oxygen speciesSynthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin.Thiol-activated DNA damage by α-bromo-2-cyclopentenone.Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator.The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural productCharacterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement.Synthesis and characterization of a small analogue of the anticancer natural product leinamycin.Possible chemical mechanisms underlying the antitumor activity of S-deoxyleinamycin.Evidence for a Morin type intramolecular cyclization of an alkene with a phenylsulfenic acid group in neutral aqueous solutionNatural product DNA major groove binders.Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics.Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140.Covalent binding to glutathione of the DNA-alkylating antitumor agent, S23906-1.Oxidative activation of leinamycin E1 triggers alkylation of guanine residues in double-stranded DNA.
P2860
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P2860
description
2000 nî lūn-bûn
@nan
2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Mechanisms of DNA damage by leinamycin.
@ast
Mechanisms of DNA damage by leinamycin.
@en
Mechanisms of DNA damage by leinamycin.
@nl
type
label
Mechanisms of DNA damage by leinamycin.
@ast
Mechanisms of DNA damage by leinamycin.
@en
Mechanisms of DNA damage by leinamycin.
@nl
prefLabel
Mechanisms of DNA damage by leinamycin.
@ast
Mechanisms of DNA damage by leinamycin.
@en
Mechanisms of DNA damage by leinamycin.
@nl
P356
P1476
Mechanisms of DNA damage by leinamycin.
@en
P2093
P304
P356
10.1021/TX000089M
P577
2000-10-01T00:00:00Z