BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. - Wikidata - awgldk - TriplyDB

BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly.

BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly.

http://www.wikidata.org/entity/Q34085175

about

MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis Mutation in PHC1 implicates chromatin remodeling in primary microcephaly pathogenesis The overexpression of MCPH1 inhibits cell growth through regulating cell cycle-related proteins and activating cytochrome c-caspase 3 signaling in cervical cancer The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution Establishment of a mouse model with misregulated chromosome condensation due to defective Mcph1 function A Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome Condensation Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1 Molecular Basis for the Association of Microcephalin (MCPH1) Protein with the Cell Division Cycle Protein 27 (Cdc27) Subunit of the Anaphase-promoting Complex Roles of Chk1 in cell biology and cancer therapy MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling Mcph1-deficient mice reveal a role for MCPH1 in otitis media Phylogeny and adaptive evolution of the brain-development gene microcephalin (MCPH1) in cetaceans Differential regulation of centrosome integrity by DNA damage response proteins.Viral regulation of aquaporin 4, connexin 43, microcephalin and nucleolin Role of BRCA1 in brain development.Positive selection on the nonhomologous end-joining factor Cernunnos-XLF in the human lineage BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer Previously described sequence variant in CDK5RAP2 gene in a Pakistani family with autosomal recessive primary microcephaly.MCPH1: a window into brain development and evolution.Genetics and biology of microcephaly and lissencephaly BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice.Deregulation of microcephalin and ASPM expression are correlated with epithelial ovarian cancer progression.Small organelle, big responsibility: the role of centrosomes in development and disease.Primary microcephaly gene MCPH1 shows a novel molecular biomarker of human renal carcinoma and is regulated by miR-27a.The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex.Mutations in WDR62, encoding a centrosomal and nuclear protein, in Indian primary microcephaly families with cortical malformations.A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells.The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.Antineoplastic effects of α-santalol on estrogen receptor-positive and estrogen receptor-negative breast cancer cells through cell cycle arrest at G2/M phase and induction of apoptosis.Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) Signaling The centrosome and its duplication cycle SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation DNA damage and breast cancer BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1.DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells Chromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment.The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex Atrazine Triggers DNA Damage Response and Induces DNA Double-Strand Breaks in MCF-10A Cells.

P2860

Q24317503-69794BD1-F3A4-41B5-9947-9EFA83F39262 Q24318539-A61EA9BB-EDF2-4127-B666-51420483E817 Q24339317-9F9ED851-B30F-4F10-9C1B-D5F72417D028 Q24652479-34A4C842-58DA-4AB1-90E7-7F9DAE3ED824 Q25255829-B69A238F-6D2B-4575-AAB2-66855553BD24 Q27334403-8707E2C3-4713-4AE2-9C4D-FAA1A1977BCA Q27658266-0B47F6DA-6EED-4CC7-8FF7-F9B2DDB4317F Q27671621-F35605F0-8300-4002-9D1A-FE8823D85C79 Q27675971-0BCF7CA1-205E-450E-93EC-4F6B823CAB9F Q28289548-954DCED5-B56A-4C43-A9D1-5129C208D795 Q28506694-07263E92-EA21-44B6-93D9-713A758DEB0B Q28513601-21CCE071-EDFF-43F8-9BFC-B82A750F88D0 Q28586091-8E3DC510-4D8D-418C-B23E-15CD1C0E812D Q28744331-073898DA-0DAE-4135-87FE-906BCB436062 Q30483874-9E49D294-8A94-45C6-B39D-F3254033973B Q30492006-55BAE4F0-AE66-4AFB-AB87-0E0A00F40673 Q30575526-C0D622D4-A75C-4187-9CB1-25D22919B352 Q33245589-D0132B6B-5898-4784-9B09-1EF04B343AE6 Q33252066-EAE5D727-65FD-4C08-9834-AF581CDB4CF6 Q33296331-16BAFF0B-9A2A-461D-AD5F-7EA315CCAA54 Q33360486-D94DEC9F-2ACF-4402-9B91-8252285B7AB9 Q33506556-9FCA7C09-3A9A-4C06-A028-D05A79EA164A Q33527006-63C4E074-8F8E-4584-B832-751EE1180A9D Q33617876-A09BE863-8445-4E24-BDD4-BE350D012CF7 Q33959953-81B025F7-67D1-4C3F-9756-CF9F26E7B452 Q34121413-45A4E774-7534-4A55-B185-36DEDED36F20 Q34131980-F7F66951-CEF5-438E-B457-0180BF63773B Q34178593-9872E95D-7C19-49B3-B244-4DA972800743 Q34404613-EFC9CCFF-FC51-4C38-845F-B0F074FB80C7 Q34541480-8E9100CD-A896-4258-A7FF-BE62A9A0CB0B Q34602854-5D8DB77B-FD8C-4E9B-B1EC-5489F4B343DE Q34634307-56E3AAEA-056B-47CE-BB0B-80AD5E0DC104 Q35045117-3A5E632B-A108-41D1-91E9-CC4F6A382C97 Q35065191-2C9453A8-A232-4B03-B329-BE7F0B869665 Q35201664-4255157B-8B2B-4273-AFF0-0674E64AFAE5 Q35212757-6289761E-AB35-4038-9A18-B54340E40003 Q35371237-C7B90AD8-26FE-4211-A2F3-F42436B3747D Q35838961-669A7A86-C4B9-4AFA-8228-B60BD2866F4A Q35873110-980993C6-A365-420A-856A-9C21AA0EFE32 Q35902382-5B1ACC2F-7BED-45E9-BD7C-DD0669452C5B

P2860

BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly.

http://www.wikidata.org/entity/Q34085175

description

2005 nî lūn-bûn

@nan

2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年学术文章

@wuu

2005年学术文章

@zh-cn

2005年学术文章

@zh-hans

2005年学术文章

@zh-my

2005年学术文章

@zh-sg

2005年學術文章

@yue

name

BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.

@ast

BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.

@en

BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.

@nl

type

label

BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.

@ast

BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.

@en

BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.

@nl

prefLabel

BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.

@ast

BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.

@en

BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.

@nl

P1433

Q34085175-5CAE5B28-762F-4C64-96CF-FD42D728F3E4

P1476

Q34085175-33F21764-0BBD-4AAE-8CC5-B5024B8AC9AE

P2093

Q34085175-11BC5077-6D7F-400A-8652-02564DC768D2

Q34085175-7B38E4F1-7378-445D-9D87-651320DF7FBA

Q34085175-89B06A95-BD98-40E3-8FFF-D50F827E060A

Q34085175-BE8DDC83-7191-4A4A-9F04-A612087DDDAC

Q34085175-C02B0A4B-7D63-4601-9743-19B4B322C599

P2860

Q34085175-054036A1-7DAD-48CD-9849-E2062C45AD8F

Q34085175-0595ED85-3168-48A6-806D-42741F45C4AF

Q34085175-1DEFCF61-F138-4FDC-9CAD-7E96E8349BC7

Q34085175-2ABB5058-7FCE-456E-B809-D4E3BD753CA9

Q34085175-2B742813-0CFE-42F0-A380-89483FD02F02

Q34085175-36065361-8859-48F2-A449-A34CE1E73EB4

Q34085175-3B209DE7-61AE-4CC7-9747-5692D091A05D

Q34085175-46F60B83-67E3-4CFB-A54E-ABD7325E1A20

Q34085175-5401706A-7272-4BE4-B9EC-DA0EED6AC6F1

Q34085175-5628EB03-612A-466F-8DD6-A81C7ECDAEE4

P304

Q34085175-EA0BB201-1E16-4E9D-B711-3DEC199224AF

P31

Q34085175-7DBC2748-9FD8-4848-B896-2BD39451AEEB

P356

Q34085175-DF458DD7-D250-4F83-A9F6-26FC7F7AB07D

P407

Q34085175-2D5A62D1-83DF-40C1-8C07-5F8FBBA4B81D

P433

Q34085175-F80FA86C-3819-4904-8D97-06965DD984BD

P478

Q34085175-9E16B070-79B8-4961-8C8D-478CBF79ABEF

P577

Q34085175-CB82E1EB-DFBB-4CED-BA8B-E13A5B5859EF

P5875

Q34085175-49B12632-B8E5-4730-98EC-78C267FDFA15

P698

Q34085175-20304F0A-0F48-49AD-BE4D-8815A7FD073D

P921

Q34085175-732EDD4B-D797-4110-94C6-DFF975C8D970

Q34085175-C1963492-DC38-41C9-95ED-3EEFC606B4A2

P932

Q34085175-50C6EC0F-FDC0-406D-AD42-4AE2338C3EAD

P356

PNAS.0507722102

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

BRIT1/MCPH1 is a DNA damage re ...... t dysfunction in microcephaly.

@en

P2093

Kaiyi Li

http://www.w3.org/2001/XMLSchema#string

Rekha Rai

http://www.w3.org/2001/XMLSchema#string

Shiaw-Yih Lin

http://www.w3.org/2001/XMLSchema#string

Stephen J Elledge

http://www.w3.org/2001/XMLSchema#string

Zhi-Xiang Xu

http://www.w3.org/2001/XMLSchema#string

P2860

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

Identification of microcephalin, a protein implicated in determining the size of the human brain

Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

Multiple tumor suppressor pathways negatively regulate telomerase

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

BRCA1 inhibition of telomerase activity in cultured cells

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

Megabase chromatin domains involved in DNA double-strand breaks in vivo

P304

15105-15109

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.0507722102

http://www.w3.org/2001/XMLSchema#string

P407

P433

42

http://www.w3.org/2001/XMLSchema#string

P478

102

http://www.w3.org/2001/XMLSchema#string

P577

2005-10-10T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

7549090

http://www.w3.org/2001/XMLSchema#string

P698

16217032

http://www.w3.org/2001/XMLSchema#string

P921

P932

1257745

http://www.w3.org/2001/XMLSchema#string