TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions
about
Systematic meta-analyses and field synopsis of genetic association studies in colorectal cancerBipartite recognition of DNA by TCF/Pangolin is remarkably flexible and contributes to transcriptional responsiveness and tissue specificity of wingless signalingWnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling.Chromatin profiling reveals regulatory network shifts and a protective role for hepatocyte nuclear factor 4α during colitis.Vitamin D and cancer: a review of molecular mechanismsCaudal homeobox protein Cdx-2 cooperates with Wnt pathway to regulate claudin-1 expression in colon cancer cells.Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2Wnt signaling specifies and patterns intestinal endoderm.VDR/RXR and TCF4/β-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression.Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells.Transcriptional networks driving enhancer function in the CFTR gene.HOXB4 Gene Expression Is Regulated by CDX2 in Intestinal Epithelial Cells.Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3.CDX2 is an amplified lineage-survival oncogene in colorectal cancer.CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5.CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling.Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding.A multi-parametric flow cytometric assay to analyze DNA-protein interactions.Identification of the MUC2 Promoter as a Strong Promoter for Intestinal Gene Expression through Generation of Transgenic Quail Expressing GFP in Gut Epithelial CellsDNA methylation is required for the control of stem cell differentiation in the small intestine.In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators.The myc 3' wnt-responsive element suppresses colonic tumorigenesis.How do they do Wnt they do?: regulation of transcription by the Wnt/β-catenin pathway.Current and emerging approaches to define intestinal epithelium-specific transcriptional networks.Review: Single nucleotide polymorphisms associated with the oncogenesis of colorectal cancer.Transcriptional networks in liver and intestinal development.Immature myeloid progenitors promote disease progression in a mouse model of Barrett's-like metaplasia.Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities.Chromatin immunoprecipitation from fixed clinical tissues reveals tumor-specific enhancer profiles.CHD6 regulates the topological arrangement of the CFTR locusLandscape of the SOX2 protein-protein interactome.ZEB1 and TCF4 reciprocally modulate their transcriptional activities to regulate Wnt target gene expression.Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells.A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.Regulation of APC and AXIN2 expression by intestinal tumor suppressor CDX2 in colon cancer cells.Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration.Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression.Wnt target genes and where to find them.Regulation of Laminin γ2 Expression by CDX2 in Colonic Epithelial Cells Is Impaired During Active Inflammation.SOX2 redirects the developmental fate of the intestinal epithelium toward a premature gastric phenotype.
P2860
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P2860
TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
TCF4 and CDX2, major transcrip ...... he same cis-regulatory regions
@ast
TCF4 and CDX2, major transcrip ...... he same cis-regulatory regions
@en
TCF4 and CDX2, major transcrip ...... he same cis-regulatory regions
@nl
type
label
TCF4 and CDX2, major transcrip ...... he same cis-regulatory regions
@ast
TCF4 and CDX2, major transcrip ...... he same cis-regulatory regions
@en
TCF4 and CDX2, major transcrip ...... he same cis-regulatory regions
@nl
prefLabel
TCF4 and CDX2, major transcrip ...... he same cis-regulatory regions
@ast
TCF4 and CDX2, major transcrip ...... he same cis-regulatory regions
@en
TCF4 and CDX2, major transcrip ...... he same cis-regulatory regions
@nl
P2093
P2860
P356
P1476
TCF4 and CDX2, major transcrip ...... he same cis-regulatory regions
@en
P2093
Duyen T Dang
Ellen Freed
Hans Clevers
Hyunjin Shin
John P Lynch
Juliet Philips
Michael P Verzi
Pantelis Hatzis
Ramesh A Shivdasani
Rita Sulahian
P2860
P304
15157-15162
P356
10.1073/PNAS.1003822107
P407
P577
2010-08-09T00:00:00Z