Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.
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Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitizationmGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in ratsThe clinical relevance of neuroplasticity in corticostriatal networks during operant learningPharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.Metabotropic glutamate receptors in the basal ganglia motor circuitMetabotropic glutamate receptor 5 (mGluR5)-mediated phosphoinositide hydrolysis and NMDA-potentiating effects are blunted in the striatum of aged rats: a possible additional mechanism in striatal senescenceMolecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment.Metabotropic glutamate receptors: from the workbench to the bedside.Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice.Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked genes PINK1 or Parkin.Memory for fear extinction requires mGluR5-mediated activation of infralimbic neuronsImaging glutamate in schizophrenia: review of findings and implications for drug discovery.Partial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects.Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal.Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seekingDysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and AutismmGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learningCognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.Pharmacological and anatomical evidence for an interaction between mGluR5- and GABA(A) alpha1-containing receptors in the discriminative stimulus effects of ethanol.Regulation of increased glutamatergic input to spinal dorsal horn neurons by mGluR5 in diabetic neuropathic pain.Cooperative signaling between homodimers of metabotropic glutamate receptors 1 and 5Development of allosteric modulators of GPCRs for treatment of CNS disordersDysregulated postsynaptic density and endocytic zone in the amygdala of human heroin and cocaine abusers.Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.Functional interaction of mGlu5 and NMDA receptors in aversive learning in rats.mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway.Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders.mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration.Dose-dependent, saturable occupancy of the metabotropic glutamate subtype 5 receptor by fenobam as measured with [(11) C]ABP688 PET imagingFunctional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.Therapeutic potential of mGluR5 targeting in Alzheimer's diseaseTherapeutic potential of metabotropic glutamate receptor modulators.mGluR5 Positive and Negative Allosteric Modulators Differentially Affect Dendritic Spine Density and Morphology in the Prefrontal CortexAltered calcium signaling following traumatic brain injuryProgress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).Neurotransmitter receptor heteromers and their integrative role in 'local modules': the striatal spine module.Translational Concepts of mGluR5 in Synaptic Diseases of the BrainAre compounds acting at metabotropic glutamate receptors the answer to treating depression?
P2860
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P2860
Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Metabotropic glutamate recepto ...... medium spiny striatal neurons.
@ast
Metabotropic glutamate recepto ...... medium spiny striatal neurons.
@en
Metabotropic glutamate recepto ...... medium spiny striatal neurons.
@nl
type
label
Metabotropic glutamate recepto ...... medium spiny striatal neurons.
@ast
Metabotropic glutamate recepto ...... medium spiny striatal neurons.
@en
Metabotropic glutamate recepto ...... medium spiny striatal neurons.
@nl
prefLabel
Metabotropic glutamate recepto ...... medium spiny striatal neurons.
@ast
Metabotropic glutamate recepto ...... medium spiny striatal neurons.
@en
Metabotropic glutamate recepto ...... medium spiny striatal neurons.
@nl
P2093
P50
P1433
P1476
Metabotropic glutamate recepto ...... medium spiny striatal neurons
@en
P2093
G Bernardi
P Calabresi
P Gubellini
P304
P356
10.1016/S0306-4522(01)00297-4
P407
P577
2001-01-01T00:00:00Z