Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling.

Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling.

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http://www.wikidata.org/entity/Q34097099
A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Molecular and genetic insights into an infantile epileptic encephalopathy - CDKL5 disorder.CDKL5 and Shootin1 Interact and Concur in Regulating Neuronal Polarization.Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth.Use of the ketogenic diet to manage refractory epilepsy in CDKL5 disorder: Experience of >100 patients.Neuronal survival in the brain: neuron type-specific mechanisms.An 18-mer Peptide Derived from Prosaposin Ameliorates the Effects of Aβ1-42 Neurotoxicity on Hippocampal Neurogenesis and Memory Deficit in Mice.CDKL5 knockout leads to altered inhibitory transmission in the cerebellum of adult mice.CDKL5 localizes at the centrosome and midbody and is required for faithful cell division.Isoflurane Is More Deleterious to Developing Brain Than Desflurane: The Role of the Akt/GSK3β Signaling Pathway.Mice lacking cyclin-dependent kinase-like 5 manifest autistic and ADHD-like behaviors.Loss of CDKL5 in Glutamatergic Neurons Disrupts Hippocampal Microcircuitry and Leads to Memory Impairment in Mice.The neurosteroid pregnenolone reverts microtubule derangement induced by the loss of a functional CDKL5-IQGAP1 complex.HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory.Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder.
P2860

Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling.

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http://www.wikidata.org/entity/Q34097099
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2014 nî lūn-bûn
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2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
Loss of CDKL5 impairs survival ...... altering AKT/GSK-3β signaling.
@ast
Loss of CDKL5 impairs survival ...... altering AKT/GSK-3β signaling.
@en
Loss of CDKL5 impairs survival ...... altering AKT/GSK-3β signaling.
@nl
type
label
Loss of CDKL5 impairs survival ...... altering AKT/GSK-3β signaling.
@ast
Loss of CDKL5 impairs survival ...... altering AKT/GSK-3β signaling.
@en
Loss of CDKL5 impairs survival ...... altering AKT/GSK-3β signaling.
@nl
prefLabel
Loss of CDKL5 impairs survival ...... altering AKT/GSK-3β signaling.
@ast
Loss of CDKL5 impairs survival ...... altering AKT/GSK-3β signaling.
@en
Loss of CDKL5 impairs survival ...... altering AKT/GSK-3β signaling.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
Loss of CDKL5 impairs survival ...... altering AKT/GSK-3β signaling
@en
P2093
P2860
P304
P31
P356
P478
P50
P577
P5875
P698
P932