PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy. - Wikidata - awgldk - TriplyDB

PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy.

PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy.

http://www.wikidata.org/entity/Q34100575

about

Histone deacetylase signaling in cardioprotection Regulation of CaMKII signaling in cardiovascular disease Metabolic reprogramming by class I and II histone deacetylases Regulation of class IIa HDAC activities: it is not only matter of subcellular localization Post-translational modifications regulate class IIa histone deacetylase (HDAC) function in health and disease Interplay of PKA and Rac: fine-tuning of Rac localization and signaling.Mice lacking the Cβ subunit of PKA are resistant to angiotensin II-induced cardiac hypertrophy and dysfunction.Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.Molecular Signals Elicited by GPCR Agonists in Hypertension, Cardiovascular Remodeling: Are MMPs and ADAMs Elusive Therapeutic Targets?Probing phosphorylation-dependent protein interactions within functional domains of histone deacetylase 5 (HDAC5).DOT1L regulates dystrophin expression and is critical for cardiac function.AMP-activated protein kinase regulates beta-catenin transcription via histone deacetylase 5.β-Adrenergic receptor stimulation and activation of protein kinase A protect against α1-adrenergic-mediated phosphorylation of protein kinase D and histone deacetylase 5 Reversal of glucose intolerance in rat offspring exposed to ethanol before birth through reduction of nuclear skeletal muscle HDAC expression by the bile acid TUDCA Roles and post-translational regulation of cardiac class IIa histone deacetylase isoforms.Histone deacetylases and cardiovascular cell lineage commitment.Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy.Acute β-adrenergic activation triggers nuclear import of histone deacetylase 5 and delays G(q)-induced transcriptional activation The Popeye Domain Containing Genes and cAMP Signaling A class of their own: exploring the nondeacetylase roles of class IIa HDACs in cardiovascular disease G9a inhibits MEF2C activity to control sarcomere assembly.Protein post-translational modifications and regulation of pluripotency in human stem cells.Class IIa HDACs: from important roles in differentiation to possible implications in tumourigenesis.Injury-induced HDAC5 nuclear export is essential for axon regeneration.Promotion and inhibition of cardiac hypertrophy by A-kinase anchor proteins.Epigenetic developmental programs and adipogenesis: implications for psychotropic induced obesity.The expanding role of epigenetics.Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes.Epigenetic modifications and noncoding RNAs in cardiac hypertrophy and failure.Gene expression profiling of HGF/Met activation in neonatal mouse heart.Angiotensin converting enzyme 2-Angiotensin 1-7/1-9 system: novel promising targets for heart failure treatment.Dual phosphorylation of Btk by Akt/protein kinase b provides docking for 14-3-3ζ, regulates shuttling, and attenuates both tonic and induced signaling in B cells.The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases.Dephosphorylation at a conserved SP motif governs cAMP sensitivity and nuclear localization of class IIa histone deacetylases.Aurora B-dependent regulation of class IIa histone deacetylases by mitotic nuclear localization signal phosphorylation.Rapid effects of aldosterone in primary cultures of cardiomyocytes - do they suggest the existence of a membrane-bound receptor?Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import.β-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55α-PP2A-Mediated Dephosphorylation.Protein kinase A-mediated phosphorylation of RhoA on serine 188 triggers the rapid induction of a neuroendocrine-like phenotype in prostate cancer epithelial cells.Approaches for Studying the Subcellular Localization, Interactions, and Regulation of Histone Deacetylase 5 (HDAC5).

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P2860

PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy.

http://www.wikidata.org/entity/Q34100575

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

PKA phosphorylates histone dea ...... and cardiomyocyte hypertrophy.

@ast

PKA phosphorylates histone dea ...... and cardiomyocyte hypertrophy.

@en

PKA phosphorylates histone dea ...... and cardiomyocyte hypertrophy.

@nl

type

label

PKA phosphorylates histone dea ...... and cardiomyocyte hypertrophy.

@ast

PKA phosphorylates histone dea ...... and cardiomyocyte hypertrophy.

@en

PKA phosphorylates histone dea ...... and cardiomyocyte hypertrophy.

@nl

prefLabel

PKA phosphorylates histone dea ...... and cardiomyocyte hypertrophy.

@ast

PKA phosphorylates histone dea ...... and cardiomyocyte hypertrophy.

@en

PKA phosphorylates histone dea ...... and cardiomyocyte hypertrophy.

@nl

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Proceedings of the National Academy of Sciences of the United States of America

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PKA phosphorylates histone dea ...... and cardiomyocyte hypertrophy.

@en

P2093

Chang Hoon Ha

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Chelsea Wong

http://www.w3.org/2001/XMLSchema#string

Ji Young Kim

http://www.w3.org/2001/XMLSchema#string

Jinjing Zhao

http://www.w3.org/2001/XMLSchema#string

Weiye Wang

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Zheng Gen Jin

http://www.w3.org/2001/XMLSchema#string

P2860

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization

Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases

Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5

Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis

Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Histone acetylation in chromatin structure and transcription

Transcriptional regulation by the phosphorylation-dependent factor CREB

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10.1073/PNAS.1000462107

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35

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107

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phosphorylation

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