Pharmacological chaperones: a new twist on receptor folding.
about
Folding efficiency is rate-limiting in dopamine D4 receptor biogenesisMolecular pathogenesis of megalencephalic leukoencephalopathy with subcortical cysts: mutations in MLC1 cause folding defectsEndoplasmic reticulum degradation impedes olfactory G-protein coupled receptor functional expressionEnhanced spontaneous activity of the mu opioid receptor by cysteine mutations: characterization of a tool for inverse agonist screeningFunctional Amyloid Signaling via the Inflammasome, Necrosome, and Signalosome: New Therapeutic Targets in Heart FailurePharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptorsGlutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.Molecular etiology of primary hyperoxaluria type 1: new directions for treatmentDysbindin promotes the post-endocytic sorting of G protein-coupled receptors to lysosomesA multiparametric computational algorithm for comprehensive assessment of genetic mutations in mucopolysaccharidosis type IIIA (Sanfilippo syndrome)Protein stability induced by ligand binding correlates with changes in protein flexibility.Amyloid beta-protein assembly as a therapeutic target of Alzheimer's disease.Trimethylamine N-oxide influence on the backbone of proteins: an oligoglycine model.Role of tyrosine 33 residue for the stabilization of the tetrameric structure of human cytidine deaminase.Pharmacological chaperones in the age of proteomic pathology.Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidaseWhen does trimethylamine N-oxide fold a polymer chain and urea unfold it?Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease.Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy.Neuronopathic Gaucher's disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds.Protein-misfolding diseases and chaperone-based therapeutic approaches.Intracellular angiotensin II: from myth to reality?Phenylalanine hydroxylase misfolding and pharmacological chaperones.Rescuing protein conformation: prospects for pharmacological therapy in cystic fibrosisCooperative stabilization of transthyretin by clusterin and diflunisal.Identification and functional characterization of rare mutations of the neuroligin-2 gene (NLGN2) associated with schizophrenia.Misrouted cell surface receptors as a novel disease aetiology and potential therapeutic target: the case of hypogonadotropic hypogonadism due to gonadotropin-releasing hormone resistance.Chemical chaperones--a new concept in drug research.Transmembrane region of N-methyl-D-aspartate receptor (NMDAR) subunit is required for receptor subunit assembly.Pharmacological chaperones for misfolded gonadotropin-releasing hormone receptorsMolecular and cellular effects of Tamm-Horsfall protein mutations and their rescue by chemical chaperones.Role of pharmacoproteomics in the development of personalized medicine.Effects of cellular, chemical, and pharmacological chaperones on the rescue of a trafficking-defective mutant of the ATP-binding cassette transporter proteins ABCB1/ABCB4.Chaperoning of the A1-adenosine receptor by endogenous adenosine - an extension of the retaliatory metabolite concept.Toward the pharmacogenomics of cystic fibrosis--an update.A cure for traffic jams: small molecule chaperones in the endoplasmic reticulum.Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease.Receptor antagonism/agonism can be uncoupled from pharmacoperone activity.Chemical chaperone rescue of mutant human cystathionine beta-synthaseDimethyl sulfoxide reduces hepatocellular lipid accumulation through autophagy induction.
P2860
Q24297696-B21ECD6D-4970-4AFB-819C-308C8931225AQ24642920-5E66D853-BD7A-4305-BABB-385686146ACAQ24795923-FF52DB92-D760-4B20-BEC0-132739528BAEQ24804972-144308DD-CC93-4E8B-91E3-410B2C4CE606Q26776120-1BB95BBC-5997-4AA8-9F81-C17A7A50F795Q26992276-38003B7E-55FB-43BE-A41A-C8D325C36C80Q27865232-7764F42E-CE61-43A4-B672-39BA939F15B9Q28257183-5CB1F9A2-12B6-4BD0-A238-7E87ACFC6527Q28472978-64E6D11C-BC2F-43C7-BD2E-48941D56F9F0Q28544979-35ED48A1-8C30-4AD8-911E-AED2409C0E2FQ30333060-47B3F023-2C71-40AF-A287-D80F5D46314EQ33392254-70BEA24D-070A-4AA3-A50C-519C34F1D050Q33587782-FC91947F-5F49-46BC-AD40-195A1DD6C4F8Q33634754-F0D4009A-5048-44EE-B3EF-55CEC560027DQ34120121-9AC945E4-312A-4546-AD91-19C9E2272D54Q34286005-45D10AA6-CE69-4ADE-A3C2-32027C809CD4Q34380720-FC36B634-525E-494D-97F3-F600D86C22D0Q34386725-236B6D36-9229-4D3E-A9F4-015622F50CE7Q34390847-F7FDC9FE-8DC6-4C95-9E1D-C03D9285D814Q34464236-61CA471F-A430-44A3-8A5E-674F869AF426Q34524526-9AD396A2-35CC-4263-A4C0-CCA97655AB6AQ34553647-055ECB14-1035-4D0B-80D4-3A1985D8B494Q34556955-56098785-BCA1-45C9-934C-38A1B63F6E2AQ34817235-97D8670E-41C3-47C2-AB78-17901D11B080Q35001154-05437AFB-E9D2-455C-B530-BB9668326D07Q35090098-8A5FD77F-91A0-4759-9C94-5A9B02E8B415Q35095132-F856201A-B3F7-4810-9C1D-E37B4D95E264Q35097487-4BB010C4-0DFD-44C7-B21C-3963DF71B00BQ35145011-6F4DF912-9A90-490B-BDC8-6E261A656CA9Q35606973-6D39A211-F906-428D-84B9-208E05E745E9Q35668819-A47F3D5E-F1F1-4740-B6CB-CAA91C8E3DD2Q35753345-51CFF4AA-7A18-4887-8B0E-37987B401F12Q35762966-5E434B4D-8A90-49BB-B6AE-B8085430275BQ35885389-7E571D52-C77D-49B8-ACD0-D58E59C043D5Q35911156-C16E2CA0-26E0-44F2-93C9-F26E4B5BAA53Q35915766-E3BFDF8D-0AF6-4DFC-959E-D0D88050D722Q35915771-E027AFEB-D67C-4F3C-B78A-A13EFFD0CC5BQ36070628-ED6FB7D2-64AC-43F2-83EB-1B4F1CB662C6Q36088268-F854DF03-0917-4BF1-91E2-1FEB928FCFD7Q36194777-A856CB07-B42F-4331-88BD-8FBBFD91E89C
P2860
Pharmacological chaperones: a new twist on receptor folding.
description
2000 nî lūn-bûn
@nan
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Pharmacological chaperones: a new twist on receptor folding.
@ast
Pharmacological chaperones: a new twist on receptor folding.
@en
Pharmacological chaperones: a new twist on receptor folding.
@nl
type
label
Pharmacological chaperones: a new twist on receptor folding.
@ast
Pharmacological chaperones: a new twist on receptor folding.
@en
Pharmacological chaperones: a new twist on receptor folding.
@nl
prefLabel
Pharmacological chaperones: a new twist on receptor folding.
@ast
Pharmacological chaperones: a new twist on receptor folding.
@en
Pharmacological chaperones: a new twist on receptor folding.
@nl
P1476
Pharmacological chaperones: a new twist on receptor folding
@en
P2093
J P Morello
U E Petäjä-Repo
P304
P356
10.1016/S0165-6147(00)01575-3
P577
2000-12-01T00:00:00Z