Expression and regulation of aggrecanase in arthritis: the role of TGF-beta. - Wikidata - awgldk - TriplyDB

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

http://www.wikidata.org/entity/Q34110312

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Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis Furin at the cutting edge: from protein traffic to embryogenesis and disease Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5 Aggrecanases and cartilage matrix degradation ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis.The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.Matrix Metalloproteinases in Non-Neoplastic Disorders.The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican Cyclical strain modulates metalloprotease and matrix gene expression in human tenocytes via activation of TGFβ Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity Altered production and proteolytic processing of brevican by transforming growth factor beta in cultured astrocytes The ADAMTS metalloproteinases ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan.Global effects of BKV infection on gene expression in human primary kidney epithelial cells.Autologous adipose stem cells and polylactide discs in the replacement of the rabbit temporomandibular joint disc.ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis.ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate In vivo experimental intervertebral disc degeneration induced by bleomycin in the rhesus monkey CCN1 (Cyr61) Is Overexpressed in Human Osteoarthritic Cartilage and Inhibits ADAMTS-4 (Aggrecanase 1) Activity.The accumulation of intracellular ITEGE and DIPEN neoepitopes in bovine articular chondrocytes is mediated by CD44 internalization of hyaluronan.Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints Prevention of progressive joint destruction in collagen-induced arthritis in rats by a novel matrix metalloproteinase inhibitor, FR255031.Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage Neuroinflammation in the aging down syndrome brain; lessons from Alzheimer's disease.Evidence for an Important Role of Smad-7 in Intervertebral Disc Degeneration.FoxC2 Enhances BMP7-Mediated Anabolism in Nucleus Pulposus Cells of the Intervertebral Disc The role of interleukin 6 in the pathophysiology of rheumatoid arthritis Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration Self-complementary adeno-associated virus serotype 6 mediated knockdown of ADAMTS4 induces long-term and effective enhancement of aggrecan in degenerative human nucleus pulposus cells: A new therapeutic approach for intervertebral disc disorders.Accelerated Chondrogenic Differentiation of Human Perivascular Stem Cells with NELL-1 An in vitro model of cartilage degradation by chondrocytes in a three-dimensional culture system.Emerging Roles of ADAMTSs in Angiogenesis and Cancer.Down's syndrome, neuroinflammation, and Alzheimer neuropathogenesis.Emerging roles of serine proteinases in tissue turnover in arthritis.Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts.Therapeutic targets in rheumatoid arthritis: the interleukin-6 receptor.Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.

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P2860

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

http://www.wikidata.org/entity/Q34110312

description

2002 nî lūn-bûn

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2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի փետրվարին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

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name

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

@ast

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

@en

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

@nl

type

label

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

@ast

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

@en

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

@nl

prefLabel

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

@ast

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

@en

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

@nl

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JIMMUNOL.168.3.1405

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Journal of Immunology

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Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

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David L Boyle

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Elizabeth C Arner

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Gary S Firestein

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Melody Clark

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Micky D Tortorella

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Rich A Maki

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Yuji Yamanishi

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1405-1412

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10.4049/JIMMUNOL.168.3.1405

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2002-02-01T00:00:00Z

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11801682

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