Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress.
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The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activityERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stressERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein CRegulated release of ERdj3 from unfolded proteins by BiPLocalization and function in endoplasmic reticulum stress tolerance of ERdj3, a new member of Hsp40 family proteinERdj3, a stress-inducible endoplasmic reticulum DnaJ homologue, serves as a cofactor for BiP's interactions with unfolded substratesMechanisms for regulation of Hsp70 function by Hsp40Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myelomaDomain architecture of protein-disulfide isomerase facilitates its dual role as an oxidase and an isomerase in Ero1p-mediated disulfide formation.Heteromeric protein complexes mediate zinc transport into the secretory pathway of eukaryotic cells.Proteasome inhibitors disrupt the unfolded protein response in myeloma cellsJPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifsGRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human diseaseThe energy hypothesis of sleep revisitedRegulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiPXBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein responseERdj4 protein is a soluble endoplasmic reticulum (ER) DnaJ family protein that interacts with ER-associated degradation machineryThe BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia.Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin.Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response.Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP.The endoplasmic reticulum-associated degradation of the epithelial sodium channel requires a unique complement of molecular chaperones.Stress response in the ascidian Ciona intestinalis: transcriptional profiling of genes for the heat shock protein 70 chaperone system under heat stress and endoplasmic reticulum stress.Hsp70 and its molecular role in nervous system diseasesA high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretionGenotoxic stress/p53-induced DNAJB9 inhibits the pro-apoptotic function of p53.Unfolded protein response-regulated Drosophila Fic (dFic) protein reversibly AMPylates BiP chaperone during endoplasmic reticulum homeostasis.Dealing with misfolded proteins: examining the neuroprotective role of molecular chaperones in neurodegeneration.HSPA5/Dna K may be a useful target for human disease therapies.The BiP cochaperone ERdj4 is required for B cell development and function.The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation.Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity.The role of p58IPK in protecting the stressed endoplasmic reticulum.Members of the Hsp70 Family Recognize Distinct Types of Sequences to Execute ER Quality Control.Versatility of the endoplasmic reticulum protein folding factory.The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulumBiP mutants that are unable to interact with endoplasmic reticulum DnaJ proteins provide insights into interdomain interactions in BiP.Protein quality control in the early secretory pathwayPushing, pulling and trapping--modes of motor protein supported protein translocation.OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies
P2860
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P2860
Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress.
description
2002 nî lūn-bûn
@nan
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Identification and characteriz ...... o and is induced by ER stress.
@ast
Identification and characteriz ...... o and is induced by ER stress.
@en
Identification and characteriz ...... o and is induced by ER stress.
@nl
type
label
Identification and characteriz ...... o and is induced by ER stress.
@ast
Identification and characteriz ...... o and is induced by ER stress.
@en
Identification and characteriz ...... o and is induced by ER stress.
@nl
prefLabel
Identification and characteriz ...... o and is induced by ER stress.
@ast
Identification and characteriz ...... o and is induced by ER stress.
@en
Identification and characteriz ...... o and is induced by ER stress.
@nl
P2093
P2860
P921
P356
P1476
Identification and characteriz ...... o and is induced by ER stress.
@en
P2093
Laurent Meunier
Linda M Hendershot
P2860
P304
15947-15956
P356
10.1074/JBC.M112214200
P407
P577
2002-02-08T00:00:00Z