Hyperosmolality in the form of elevated NaCl but not urea causes DNA damage in murine kidney cells.
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TAO kinases mediate activation of p38 in response to DNA damageMKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38deltaThe combinatorial nature of osmosensing in fishesTransgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaksIntracellular water homeostasis and the mammalian cellular osmotic stress responseMouse TonEBP-NFAT5: expression in early development and alternative splicingSalt ToleranceGadd45 proteins induce G2/M arrest and modulate apoptosis in kidney cells exposed to hyperosmotic stress.Increased cancer risk of augmentation cystoplasty: possible role for hyperosmolal microenvironment on DNA damage recognitionMediator of DNA damage checkpoint 1 (MDC1) contributes to high NaCl-induced activation of the osmoprotective transcription factor TonEBP/OREBP.Rapid hyperosmotic coinduction of two tilapia (Oreochromis mossambicus) transcription factors in gill cells.Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase.Ku86 preserves chromatin integrity in cells adapted to high NaCl.ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress.Differential transcriptomic analyses revealed genes and signaling pathways involved in iono-osmoregulation and cellular remodeling in the gills of euryhaline Mozambique tilapia, Oreochromis mossambicusATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP.Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation.ABCC1 is related to the protection of the distal nephron against hyperosmolality and high sodium environment: possible implications for cancer chemotherapyMre11 is expressed in mammalian mitochondria where it binds to mitochondrial DNA.Hyperosmolality triggers oxidative damage in kidney cells.High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8-oxoguanine lesions in their DNAProteomic analysis of cross protection provided between cold and osmotic stress in Listeria monocytogenes.DNA double-strand breaks induced by high NaCl occur predominantly in gene desertsMAP kinases and the adaptive response to hypertonicity: functional preservation from yeast to mammals.DNA damage and osmotic regulation in the kidney.Impact of anisosmotic conditions on structural and functional integrity of cumulus-oocyte complexes at the germinal vesicle stage in the domestic cat.The activation of p38 MAPK limits the abnormal proliferation of vascular smooth muscle cells induced by high sodium concentrations.Transcription of Satellite III non-coding RNAs is a general stress response in human cellsCells adapted to high NaCl have many DNA breaks and impaired DNA repair both in cell culture and in vivo.Osmoadaptation of Mammalian cells - an orchestrated network of protective genesNFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment.Analysis of DNA breaks, DNA damage response, and apoptosis produced by high NaCl.Role of cold shock proteins in growth of Listeria monocytogenes under cold and osmotic stress conditions.DNA damage evaluated by gammaH2AX foci formation by a selective group of chemical/physical stressors.Ambient tonicity and intestinal cytochrome CYP3A.Effect of osmotic shock and urea on phosphatidylserine scrambling in thrombocyte cell membranes.Deciphering the Code of the Cancer Genome: Mechanisms of Chromosome Rearrangement.Severe acute dehydration in a desert rodent elicits a transcriptional response that effectively prevents kidney injury.TonEBP/NFAT5 stimulates transcription of HSP70 in response to hypertonicity.Prostaglandin E2 stimulates expression of osmoprotective genes in MDCK cells and promotes survival under hypertonic conditions.
P2860
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P2860
Hyperosmolality in the form of elevated NaCl but not urea causes DNA damage in murine kidney cells.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Hyperosmolality in the form of ...... damage in murine kidney cells.
@ast
Hyperosmolality in the form of ...... damage in murine kidney cells.
@en
Hyperosmolality in the form of ...... damage in murine kidney cells.
@nl
type
label
Hyperosmolality in the form of ...... damage in murine kidney cells.
@ast
Hyperosmolality in the form of ...... damage in murine kidney cells.
@en
Hyperosmolality in the form of ...... damage in murine kidney cells.
@nl
prefLabel
Hyperosmolality in the form of ...... damage in murine kidney cells.
@ast
Hyperosmolality in the form of ...... damage in murine kidney cells.
@en
Hyperosmolality in the form of ...... damage in murine kidney cells.
@nl
P2860
P356
P1476
Hyperosmolality in the form of ...... damage in murine kidney cells.
@en
P2093
D Chakravarty
P2860
P304
P356
10.1073/PNAS.98.4.1999
P407
P577
2001-02-01T00:00:00Z