ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP. - Wikidata - awgldk - TriplyDB

ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP.

ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP.

http://www.wikidata.org/entity/Q34515847

about

How do kinases contribute to tonicity-dependent regulation of the transcription factor NFAT5?Intracellular water homeostasis and the mammalian cellular osmotic stress response c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC Phospholipase C-gamma1 is involved in signaling the activation by high NaCl of the osmoprotective transcription factor TonEBP/OREBP.Osmoprotective transcription factor NFAT5/TonEBP modulates nuclear factor-kappaB activity.Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice.The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress.Increased cancer risk of augmentation cystoplasty: possible role for hyperosmolal microenvironment on DNA damage recognition Inducible nucleosome depletion at OREBP-binding-sites by hypertonic stress.Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP Macrophages in homeostatic immune function.Mediator of DNA damage checkpoint 1 (MDC1) contributes to high NaCl-induced activation of the osmoprotective transcription factor TonEBP/OREBP.Mechanistic heterogeneity in site recognition by the structurally homologous DNA-binding domains of the ETS family transcription factors Ets-1 and PU.1.NFAT5 is activated by hypoxia: role in ischemia and reperfusion in the rat kidney.Tonicity-responsive microRNAs contribute to the maximal induction of osmoregulatory transcription factor OREBP in response to high-NaCl hypertonicity High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization.Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation.Drying and salting send different messages.MAP kinases and the adaptive response to hypertonicity: functional preservation from yeast to mammals.Stress-induced corneal epithelial apoptosis mediated by K+ channel activation DNA damage and osmotic regulation in the kidney.Effect of specific activation of γ-aminobutyric acid receptor in vivo on oxidative stress-induced damage after extended hepatectomy.Mutations that reduce its specific DNA binding inhibit high NaCl-induced nuclear localization of the osmoprotective transcription factor NFAT5 Elevated extracellular glucose and uncontrolled type 1 diabetes enhance NFAT5 signaling and disrupt the transverse tubular network in mouse skeletal muscle Osmotic stress and the cytoskeleton: the R(h)ole of Rho GTPases.Osmoadaptation of Mammalian cells - an orchestrated network of protective genes Inhibitory phosphorylation of GSK-3β by AKT, PKA, and PI3K contributes to high NaCl-induced activation of the transcription factor NFAT5 (TonEBP/OREBP)Peptide affinity analysis of proteins that bind to an unstructured NH2-terminal region of the osmoprotective transcription factor NFAT5.NFAT5 in cellular adaptation to hypertonic stress - regulations and functional significance Analysis of DNA breaks, DNA damage response, and apoptosis produced by high NaCl.A dimer-specific function of the transcription factor NFATp.High NaCl-induced inhibition of PTG contributes to activation of NFAT5 through attenuation of the negative effect of SHP-1.Pretreatment of Small-for-Size Grafts In Vivo by γ -Aminobutyric Acid Receptor Regulation against Oxidative Stress-Induced Injury in Rat Split Orthotopic Liver Transplantation Liver graft pretreated in vivo or ex vivo by γ-aminobutyric acid receptor regulation.Cellular stress response pathway system as a sentinel ensemble in toxicological screening.Pretreatment of liver grafts in vivo by γ-aminobutyric acid receptor regulation reduces cold ischemia/warm reperfusion injury in rat.Oxidative stress and extracellular matrices after hepatectomy and liver transplantation in rats Ambient tonicity and intestinal cytochrome CYP3A.14-3-3-β and -{varepsilon} contribute to activation of the osmoprotective transcription factor NFAT5 by increasing its protein abundance and its transactivating activity.

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P2860

ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP.

http://www.wikidata.org/entity/Q34515847

description

2004 nî lūn-bûn

@nan

2004 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2004年の論文

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2004年論文

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2004年論文

@zh-hant

2004年論文

@zh-hk

2004年論文

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2004年論文

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2004年论文

@wuu

name

ATM, a DNA damage-inducible ki ...... scription factor TonEBP/OREBP.

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ATM, a DNA damage-inducible ki ...... scription factor TonEBP/OREBP.

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ATM, a DNA damage-inducible ki ...... scription factor TonEBP/OREBP.

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type

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ATM, a DNA damage-inducible ki ...... scription factor TonEBP/OREBP.

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ATM, a DNA damage-inducible ki ...... scription factor TonEBP/OREBP.

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ATM, a DNA damage-inducible ki ...... scription factor TonEBP/OREBP.

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Proceedings of the National Academy of Sciences of the United States of America

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ATM, a DNA damage-inducible ki ...... scription factor TonEBP/OREBP.

@en

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Carlos E Irarrazabal

http://www.w3.org/2001/XMLSchema#string

Jennifer C Liu

http://www.w3.org/2001/XMLSchema#string

Joan D Ferraris

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Maurice B Burg

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P2860

Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity

Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

Activity of the TonEBP/OREBP transactivation domain varies directly with extracellular NaCl concentration.

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

Purification, identification, and characterization of an osmotic response element binding protein

The NFAT-related protein NFATL1 (TonEBP/NFAT5) is induced upon T cell activation in a calcineurin-dependent manner

Fyn and p38 signaling are both required for maximal hypertonic activation of the osmotic response element-binding protein/tonicity-responsive enhancer-binding protein (OREBP/TonEBP)

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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10.1073/PNAS.0403062101

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101

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15173573

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