A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain
about
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel familyTransient receptor potential (TRP) channels as drug targets for diseases of the digestive systemA venom-derived neurotoxin, CsTx-1, from the spider Cupiennius salei exhibits cytolytic activitiesCapsaicin, Nociception and PainCentipede venoms and their components: resources for potential therapeutic applicationsFrom foe to friend: using animal toxins to investigate ion channel functionFunctionally important amino acid residues in the transient receptor potential vanilloid 1 (TRPV1) ion channel--an overview of the current mutational dataCalcium influx pathways in breast cancer: opportunities for pharmacological interventionω-Tbo-IT1-New Inhibitor of Insect Calcium Channels Isolated from Spider Venom.A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1.Asteropsin A: An unusual cystine-crosslinked peptide from porifera enhances neuronal Ca2+ influxTRPV1 structures in distinct conformations reveal activation mechanismsIon-channel modulators: more diversity than previously thoughtOptical control of TRPV1 channelsTRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid actionSelective spider toxins reveal a role for the Nav1.1 channel in mechanical painScorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 ChannelExploring functional roles of TRPV1 intracellular domains with unstructured peptide-insertion screeningEffect of cholesterol depletion on the pore dilation of TRPV1.Modular toxin from the lynx spider Oxyopes takobius: Structure of spiderine domains in solution and membrane-mimicking environment.Transient receptor potential (TRP) channels: a clinical perspectiveTRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity.TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice.Toxin diversity revealed by a transcriptomic study of Ornithoctonus huwena.Functional agonism of insect odorant receptor ion channelsHigh temperature sensitivity is intrinsic to voltage-gated potassium channels.Receptor-targeting mechanisms of pain-causing toxins: How ow?High yield production and refolding of the double-knot toxin, an activator of TRPV1 channels.TRPV1 mediates cellular uptake of anandamide and thus promotes endothelial cell proliferation and network-formation.Mechanisms involved in the nociception triggered by the venom of the armed spider Phoneutria nigriventer.Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli.Structural interactions of a voltage sensor toxin with lipid membranes.The history of the Drosophila TRP channel: the birth of a new channel superfamilyA new theraphosid spider toxin causes early insect cell death by necrosis when expressed in vitro during recombinant baculovirus infection.Nobilamides A-H, long-acting transient receptor potential vanilloid-1 (TRPV1) antagonists from mollusk-associated bacteriaRole of the outer pore domain in transient receptor potential vanilloid 1 dynamic permeability to large cationsStructure of the yellow sac spider Cheiracanthium punctorium genes provides clues to evolution of insecticidal two-domain knottin toxins.Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli.Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels.A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
P2860
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P2860
A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A bivalent tarantula toxin act ...... argeting the outer pore domain
@ast
A bivalent tarantula toxin act ...... argeting the outer pore domain
@en
A bivalent tarantula toxin act ...... argeting the outer pore domain
@nl
type
label
A bivalent tarantula toxin act ...... argeting the outer pore domain
@ast
A bivalent tarantula toxin act ...... argeting the outer pore domain
@en
A bivalent tarantula toxin act ...... argeting the outer pore domain
@nl
prefLabel
A bivalent tarantula toxin act ...... argeting the outer pore domain
@ast
A bivalent tarantula toxin act ...... argeting the outer pore domain
@en
A bivalent tarantula toxin act ...... argeting the outer pore domain
@nl
P2093
P2860
P1433
P1476
A bivalent tarantula toxin act ...... argeting the outer pore domain
@en
P2093
Christopher J Bohlen
David Julius
David King
Jan Siemens
Sharleen Zhou
P2860
P304
P356
10.1016/J.CELL.2010.03.052
P407
P50
P577
2010-05-01T00:00:00Z