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Portability of paddle motif function and pharmacology in voltage sensors

Portability of paddle motif function and pharmacology in voltage sensors

http://www.wikidata.org/entity/Q24649968

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Renewable Energy Driven by Le Chatelier's Principle, Enzyme Function, and Non-Additive Contributions to Ion Fluctuations: A Hypothesis in Biomechanical and Nanotechnology Energy Theory Water wires in atomistic models of the Hv1 proton channel Voltage-sensing domain of voltage-gated proton channel Hv1 shares mechanism of block with pore domains Functionality of the voltage-gated proton channel truncated in S4 Solution structure of GxTX-1E, a high-affinity tarantula toxin interacting with voltage sensors in Kv2.1 potassium channels Interactions between lipids and voltage sensor paddles detected with tarantula toxins From foe to friend: using animal toxins to investigate ion channel function Solution Structure and Phospholipid Interactions of the Isolated Voltage-Sensor Domain from KvAP Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K + channel A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist Drosophila sodium channel mutations: Contributions to seizure-susceptibility A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family Insights into the structure and function of HV1 from a meta-analysis of mutation studies The Voltage-Gated Proton Channel: A Riddle, Wrapped in a Mystery, inside an Enigma.Regulation of KCNQ/Kv7 family voltage-gated K+ channels by lipids.S1 constrains S4 in the voltage sensor domain of Kv7.1 K+ channels.Engineering of a genetically encodable fluorescent voltage sensor exploiting fast Ci-VSP voltage-sensing movements.Structure and hydration of membranes embedded with voltage-sensing domains.An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1.Targeting voltage sensors in sodium channels with spider toxins.Transfer of ion binding site from ether-a-go-go to Shaker: Mg2+ binds to resting state to modulate channel opening Down-state model of the voltage-sensing domain of a potassium channel.In pursuit of an inhibitory drug for the proton channel Structure and orientation of a voltage-sensor toxin in lipid membranes.Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures.Receptor-targeting mechanisms of pain-causing toxins: How ow?Voltage-gated proton channels.Structural interactions between lipids, water and S1-S4 voltage-sensing domains A shaker K+ channel with a miniature engineered voltage sensor.Voltage-gated proton channels find their dream job managing the respiratory burst in phagocytes.Structural interactions of a voltage sensor toxin with lipid membranes.Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.Voltage-sensing phosphatase: actions and potentials.A surface plasmon resonance approach to monitor toxin interactions with an isolated voltage-gated sodium channel paddle motif.Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors

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P2860

Portability of paddle motif function and pharmacology in voltage sensors

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description

2007 nî lūn-bûn

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2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2007 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Portability of paddle motif function and pharmacology in voltage sensors

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Portability of paddle motif function and pharmacology in voltage sensors

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Portability of paddle motif function and pharmacology in voltage sensors

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Portability of paddle motif function and pharmacology in voltage sensors

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Portability of paddle motif function and pharmacology in voltage sensors

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Portability of paddle motif function and pharmacology in voltage sensors

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Portability of paddle motif function and pharmacology in voltage sensors

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Portability of paddle motif function and pharmacology in voltage sensors

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Portability of paddle motif function and pharmacology in voltage sensors

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Abdulrasheed A Alabi

http://www.w3.org/2001/XMLSchema#string

Hoi Jong Jung

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Jae Il Kim

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Kenton J Swartz

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Maria Isabel Bahamonde

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P2860

X-ray structure of a voltage-dependent K+ channel

A voltage-gated proton-selective channel lacking the pore domain

A voltage sensor-domain protein is a voltage-gated proton channel

Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane

Tarantula toxins interact with voltage sensors within lipid membranes

Solution structure and functional characterization of SGTx1, a modifier of Kv2.1 channel gating

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

Isolation and pharmacological characterization of omega-grammotoxin SIA, a novel peptide inhibitor of neuronal voltage-sensitive calcium channel responses

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370-5

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10.1038/NATURE06266

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450

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