Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states.
about
Structural basis for complement factor I control and its disease-associated sequence polymorphismsInteraction of Thrombin with Sucrose OctasulfateEssential role of conformational selection in ligand bindingGpIbα Interacts Exclusively with Exosite II of ThrombinTargeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effectsDesigning Allosteric Regulators of Thrombin. Exosite 2 Features Multiple Subsites That Can Be Targeted by Sulfated Small Molecules for Inducing InhibitionCorrelated motions and residual frustration in thrombin.Promiscuous and specific recognition among ephrins and Eph receptorsApplications of isothermal titration calorimetry in pure and applied research--survey of the literature from 2010.Evidence of the E*-E equilibrium from rapid kinetics of Na+ binding to activated protein C and factor Xa.Kinetic dissection of the pre-existing conformational equilibrium in the trypsin fold.Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite FunctionConformational selection in trypsin-like proteases.Meizothrombin is an unexpectedly zymogen-like variant of thrombin.Effect of zymogen domains and active site occupation on activation of prothrombin by von Willebrand factor-binding protein.Ligand binding to anion-binding exosites regulates conformational properties of thrombin.Design of Factor XIII V34X activation peptides to control ability to interact with thrombin mutants.The Fragment 1 Region of Prothrombin Facilitates the Favored Binding of Fragment 12 to Zymogen and Enforces Zymogen-like Character in the Proteinase.The transition of prothrombin to thrombin.Protease-activated receptors in hemostasis.Large-scale molecular dynamics simulation: Effect of polarization on thrombin-ligand binding energyProtease-activated receptor 1 (PAR1) and PAR4 heterodimers are required for PAR1-enhanced cleavage of PAR4 by α-thrombin.NMR reveals a dynamic allosteric pathway in thrombin.Thermodynamic compensation upon binding to exosite 1 and the active site of thrombinTargeting the anionic region of human protease-activated receptor 4 inhibits platelet aggregation and thrombosis without interfering with hemostasis.Role of glycine 221 in catalytic activity of hyaluronan-binding protein 2.Interplay between conformational selection and zymogen activation.Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis
P2860
Q24622871-2591D50A-7E03-47B7-A168-D800146E09C2Q27670722-003072A6-A8E7-4C03-9B52-C4E9D008B4CFQ27680217-0AE562FA-62DB-4B50-8B0C-E28765A685CDQ27680808-071253C0-19AA-41EE-9AE6-5F372B052677Q28236023-EA292A1E-6F25-4CF9-AFE8-E787B8943D2EQ29040782-B5DCD95A-4B44-4836-BA4C-71385A1E9D83Q30155107-1FEE0C5C-A31E-47EB-B71A-AF7D1A0C0F62Q34150471-9B107C82-69F0-4C15-A509-88446987D31EQ34244067-7C6F5DBA-5F82-44E8-B9AC-E1DE6DC93D3BQ34630229-A738F8FF-2E5A-4D6C-812E-06103CD00AB2Q36049897-1476654C-AA1B-405F-AB8A-822646130065Q36053189-CB490A1F-21DE-46BB-9C84-575BEA762DB0Q36177002-846D4766-367C-43C7-9DF3-66EB6615F3E8Q36216378-50C91D69-9291-443D-963B-50100F2B7BEAQ36385980-6A224155-8D4A-4A65-A7BC-104FA7615C44Q36708674-10963F47-FD70-4DA0-840B-FB5C10E60E29Q36819410-5E23156A-0643-4066-AD38-F850190B17CEQ36987640-20155A10-E04A-462A-A058-5012FAF2544EQ37019579-1CBA45D6-AF1A-407A-9144-FA465BFCF332Q37097085-E78F3B28-0EAF-4A52-89FA-1A869919AF0EQ37163377-8A9F77D8-F233-42D0-B4CD-DB3D709D3A37Q37289265-9005EC4B-3B46-4E7C-A9B4-834027B68891Q37563464-66E64067-548D-431E-98CE-6DE99DF20053Q38335640-FE448B9D-1878-4A0C-A7E3-2401FBF697CCQ41810106-12844FA9-7E2E-4F0F-985C-72A910CC7A4EQ51118156-0066D2C4-4E00-4267-B60F-CD8888BD673DQ52728424-A98D5EF4-5457-457E-A0E3-E1CF3FE780CCQ58895615-63502FE5-2C9C-47C4-A996-221DE9950CAD
P2860
Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Ligand binding shuttles thromb ...... n- and proteinase-like states.
@ast
Ligand binding shuttles thromb ...... n- and proteinase-like states.
@en
Ligand binding shuttles thromb ...... n- and proteinase-like states.
@nl
type
label
Ligand binding shuttles thromb ...... n- and proteinase-like states.
@ast
Ligand binding shuttles thromb ...... n- and proteinase-like states.
@en
Ligand binding shuttles thromb ...... n- and proteinase-like states.
@nl
prefLabel
Ligand binding shuttles thromb ...... n- and proteinase-like states.
@ast
Ligand binding shuttles thromb ...... n- and proteinase-like states.
@en
Ligand binding shuttles thromb ...... n- and proteinase-like states.
@nl
P2093
P2860
P356
P1476
Ligand binding shuttles thromb ...... n- and proteinase-like states.
@en
P2093
James A Huntington
Parvathi Kamath
Sriram Krishnaswamy
P2860
P304
28651-28658
P356
10.1074/JBC.M110.154914
P407
P577
2010-07-16T00:00:00Z