Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas.

Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas.

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http://www.wikidata.org/entity/Q34130042
Nuclear hormone receptor functions in keratinocyte and melanocyte homeostasis, epidermal carcinogenesis and melanomagenesisRetinoid-X-receptors (α/β) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV irradiationSelective ablation of Ctip2/Bcl11b in epidermal keratinocytes triggers atopic dermatitis-like skin inflammatory responses in adult mice.RXRα ablation in epidermal keratinocytes enhances UVR-induced DNA damage, apoptosis, and proliferation of keratinocytes and melanocytes.Loss of keratinocytic RXRα combined with activated CDK4 or oncogenic NRAS generates UVB-induced melanomas via loss of p53 and PTEN in the tumor microenvironment.Transcription Factor CTIP2 Maintains Hair Follicle Stem Cell Pool and Contributes to Altered Expression of LHX2 and NFATC1Expression of the vitamin D-activating enzyme 1α-hydroxylase (CYP27B1) decreases during melanoma progressionTranscription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.CDK4: A Key Player in the Cell Cycle, Development, and CancerEndothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates ultraviolet-induced melanocyte homeostasis.Modelling melanoma in mice.Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development.Nuclear expression of CDK4 correlates with disease progression and poor prognosis in human nasopharyngeal carcinoma.Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas.
P2860

Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas.

Item
http://www.wikidata.org/entity/Q34130042
description
2010 nî lūn-bûn
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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Loss of nuclear receptor RXRα ...... -activated invasive melanomas.
@ast
Loss of nuclear receptor RXRα ...... -activated invasive melanomas.
@en
Loss of nuclear receptor RXRα ...... -activated invasive melanomas.
@nl
type
label
Loss of nuclear receptor RXRα ...... -activated invasive melanomas.
@ast
Loss of nuclear receptor RXRα ...... -activated invasive melanomas.
@en
Loss of nuclear receptor RXRα ...... -activated invasive melanomas.
@nl
prefLabel
Loss of nuclear receptor RXRα ...... -activated invasive melanomas.
@ast
Loss of nuclear receptor RXRα ...... -activated invasive melanomas.
@en
Loss of nuclear receptor RXRα ...... -activated invasive melanomas.
@nl
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P698
P932
P356
P1433
P1476
Loss of nuclear receptor RXRα ...... -activated invasive melanomas.
@en
P2093
P2860
P304
P31
P356
10.1111/J.1755-148X.2010.00732.X
P433
P478
P577
P698
P932