mTOR signaling in glioblastoma: lessons learned from bench to bedside. - Wikidata - awgldk - TriplyDB

mTOR signaling in glioblastoma: lessons learned from bench to bedside.

mTOR signaling in glioblastoma: lessons learned from bench to bedside.

http://www.wikidata.org/entity/Q34133033

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ROS and Brain Gliomas: An Overview of Potential and Innovative Therapeutic Strategies Therapeutic interactions of autophagy with radiation and temozolomide in glioblastoma: evidence and issues to resolve Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date Deregulated signaling pathways in glioblastoma multiforme: molecular mechanisms and therapeutic targets A critical evaluation of PI3K inhibition in Glioblastoma and Neuroblastoma therapy Nogo limits neural plasticity and recovery from injury Mining TCGA data using Boolean implications EGF signalling and rapamycin-mediated mTOR inhibition in glioblastoma multiforme evaluated by phospho-specific flow cytometry.Preclinical therapeutic efficacy of a novel blood-brain barrier-penetrant dual PI3K/mTOR inhibitor with preferential response in PI3K/PTEN mutant glioma.Molecular targeting of glioblastoma: Drug discovery and therapies Review: molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapies Drugs acting on homeostasis: challenging cancer cell adaptation.Glial progenitors as targets for transformation in glioma.Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity.Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma.Tumor cells switch to mitochondrial oxidative phosphorylation under radiation via mTOR-mediated hexokinase II inhibition--a Warburg-reversing effect Tetraspanin 8-rictor-integrin α3 complex is required for glioma cell migration.A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma Therapy.Significance of filamin A in mTORC2 function in glioblastoma Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C kinases.Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737-Mediated Cell Death in Malignant Human Glioma Cell Lines.Emerging insights into the molecular and cellular basis of glioblastoma.Exploring the key genes and signaling transduction pathways related to the survival time of glioblastoma multiforme patients by a novel survival analysis model.Hypoxia induces a phase transition within a kinase signaling network in cancer cells Combination of an anti-EGFRvIII antibody CH12 with Rapamycin synergistically inhibits the growth of EGFRvIII+PTEN-glioblastoma in vivo.Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition.The mTORC1/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells.The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas.MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.Standards of care and novel approaches in the management of glioblastoma multiforme.MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling.Review of the complexities of the PI3K/mTOR pathway presages similar handling of other critical topics Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: novel therapeutic agents and advances in understanding.The impact of age on oncogenic potential: tumor-initiating cells and the brain microenvironment.Recent advances in targeted therapy for glioblastoma.Therapeutic potential of mTOR inhibitors for targeting cancer stem cells.Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma.Feedback circuitry between miR-218 repression and RTK activation in glioblastoma.An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway.

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mTOR signaling in glioblastoma: lessons learned from bench to bedside.

http://www.wikidata.org/entity/Q34133033

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

mTOR signaling in glioblastoma: lessons learned from bench to bedside.

@ast

mTOR signaling in glioblastoma: lessons learned from bench to bedside.

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mTOR signaling in glioblastoma: lessons learned from bench to bedside.

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type

label

mTOR signaling in glioblastoma: lessons learned from bench to bedside.

@ast

mTOR signaling in glioblastoma: lessons learned from bench to bedside.

@en

mTOR signaling in glioblastoma: lessons learned from bench to bedside.

@nl

prefLabel

mTOR signaling in glioblastoma: lessons learned from bench to bedside.

@ast

mTOR signaling in glioblastoma: lessons learned from bench to bedside.

@en

mTOR signaling in glioblastoma: lessons learned from bench to bedside.

@nl

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mTOR signaling in glioblastoma: lessons learned from bench to bedside.

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David Akhavan

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Paul S Mischel

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Timothy F Cloughesy

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P2860

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

AMPK phosphorylation of raptor mediates a metabolic checkpoint

An integrated genomic analysis of human glioblastoma multiforme

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

A drosophila model for EGFR-Ras and PI3K-dependent human glioma

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

Mutations of the BRAF gene in human cancer

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

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