Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia. - Wikidata - awgldk - TriplyDB

Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia.

Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia.

http://www.wikidata.org/entity/Q34133670

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LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear Caenorhabditis elegans SMA-10/LRIG is a conserved transmembrane protein that enhances bone morphogenetic protein signaling Lrig2-deficient mice are protected against PDGFB-induced glioma Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear.Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis.Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor The LRIG family: enigmatic regulators of growth factor receptor signaling.The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases.The epidermal growth factor receptor family: biology driving targeted therapeutics.Epiprofin orchestrates epidermal keratinocyte proliferation and differentiation Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing Field LRIG1 as a potential novel marker for neoplastic transformation in ocular surface squamous neoplasia Lrig1 is an estrogen-regulated growth suppressor and correlates with longer relapse-free survival in ERα-positive breast cancer.LRIG and cancer prognosis.Negative regulation of ErbB family receptor tyrosine kinases Senescent Atrophic Epidermis Retains Lrig1+ Stem Cells and Loses Wnt Signaling, a Phenotype Shared with CD44KO Mice.Skin stem cells: rising to the surface.LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cells.Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancer.The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status.Mechanisms of ErbB receptor negative regulation and relevance in cancer.LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development.LRIG1 is a triple threat: ERBB negative regulator, intestinal stem cell marker and tumour suppressor.LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII.Lrig1 is a cell-intrinsic modulator of hippocampal dendrite complexity and BDNF signaling.LRIG1, a candidate tumour-suppressor gene in human bladder cancer cell line BIU87.Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis Lrig1 Expression in Human Sebaceous Gland Tumors.Role of LIM kinases in normal and psoriatic human epidermis.The interfollicular epidermis of adult mouse tail comprises two distinct cell lineages that are differentially regulated by Wnt, Edaradd, and Lrig1.LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis.A soluble ectodomain of LRIG1 inhibits cancer cell growth by attenuating basal and ligand-dependent EGFR activity.Feedback regulation of RTK signaling in development.A protein interaction network centered on leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) regulates growth factor receptors.Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma.LRIG1 negatively regulates RET mutants and is downregulated in thyroid cancer.Cardiac hypertrophy and decreased high-density lipoprotein cholesterol in Lrig3-deficient mice.

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P2860

Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia.

http://www.wikidata.org/entity/Q34133670

description

2002 nî lūn-bûn

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2002 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2002 թվականի հունիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia.

@ast

Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia.

@en

Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia.

@nl

type

label

Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia.

@ast

Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia.

@en

Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia.

@nl

prefLabel

Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia.

@ast

Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia.

@en

Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia.

@nl

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Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia.

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Atsushi Tanemura

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Aya Nakata

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Gen Kondoh

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Hiroyuki Miura

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Kentaro Ozawa

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Kinji Kobayashi

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Kunihiko Yoshikawa

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Masaya Tohyama

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Satoshi Itami

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Shigeki Inui

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Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype

The leucine-rich repeat: a versatile binding motif

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells

Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis

Enrichment for murine keratinocyte stem cells based on cell surface phenotype

Kinetics and regulation of human keratinocyte stem cell growth in short-term primary ex vivo culture. Cooperative growth factors from psoriatic lesional T lymphocytes stimulate proliferation among psoriatic uninvolved, but not normal, stem keratinoc

cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains.

Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation

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