Knockout mice: simple solutions to the problems of genetic background and flanking genes.
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Reduced body weight is a common effect of gene knockout in miceThe significance of meaning: why do over 90% of behavioral neuroscience results fail to translate to humans, and what can we do to fix it?Mice with deficient BK channel function show impaired prepulse inhibition and spatial learning, but normal working and spatial reference memory.A high through-put reverse genetic screen identifies two genes involved in remote memory in miceInsufficiently defined genetic background confounds phenotypes in transgenic studies as exemplified by malaria infection in Tlr9 knockout micePhenotypic consequences of copy number variation: insights from Smith-Magenis and Potocki-Lupski syndrome mouse modelsIncreased response to morphine in mice lacking protein kinase C epsilonElevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2D5 dopamine receptor regulation of phospholipase DGenetic targeting of NRXN2 in mice unveils role in excitatory cortical synapse function and social behaviorsCry, baby, cry: Expression of Distress as a Biomarker and Modulator in Autism Spectrum DisorderCopy number variation at 22q11.2: from rare variants to common mechanisms of developmental neuropsychiatric disorders.Evaluation of social and physical enrichment in modulation of behavioural phenotype in C57BL/6J female miceImpaired Pavlovian fear extinction is a common phenotype across genetic lineages of the 129 inbred mouse strain.Sept5 deficiency exerts pleiotropic influence on affective behaviors and cognitive functions in miceGenetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.TIP39 modulates effects of novelty-induced arousal on memory.High-throughput phenotyping of avoidance learning in mice discriminates different genotypes and identifies a novel gene.MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adultsThe separate and combined effects of MHC genotype, parasite clone, and host gender on the course of malaria in mice.Clustered gene expression changes flank targeted gene loci in knockout mice.Cortactin is implicated in murine zygotic development.Imprinted Nesp55 influences behavioral reactivity to novel environmentsStrain background effects and genetic modifiers of hearing in mice.Mouse Models of 22q11.2-Associated Autism Spectrum DisorderInterleukin-1beta contributes to the generation of experimental febrile seizuresDietary regimens modify early onset of obesity in mice haploinsufficient for Rai1.Behavioral and genetic investigations of low exploratory behavior in Il18r1(-/-) mice: we can't always blame it on the targeted geneAltered social behaviours in neurexin 1α knockout mice resemble core symptoms in neurodevelopmental disorders.The course of malaria in mice: major histocompatibility complex (MHC) effects, but no general MHC heterozygote advantage in single-strain infections.Effect of crossing C57BL/6 and FVB mouse strains on basal cytokine expression.The relevance of individual genetic background and its role in animal models of epilepsySex Differences in Ethanol's Anxiolytic Effect and Chronic Ethanol Withdrawal Severity in Mice with a Null Mutation of the 5α-Reductase Type 1 Gene.Neuromodulatory role of endogenous interleukin-1β in acute seizures: possible contribution of cyclooxygenase-2Impaired neutrophil activity and increased susceptibility to bacterial infection in mice lacking glucose-6-phosphatase-beta.Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity.Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.Interpretation of knockout experiments: the congenic footprint.Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence.Targeted deletion of Vglut2 expression in the embryonal telencephalon promotes an anxiolytic phenotype of the adult mouse
P2860
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P2860
Knockout mice: simple solutions to the problems of genetic background and flanking genes.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Knockout mice: simple solutions to the problems of genetic background and flanking genes.
@ast
Knockout mice: simple solutions to the problems of genetic background and flanking genes.
@en
Knockout mice: simple solutions to the problems of genetic background and flanking genes.
@nl
type
label
Knockout mice: simple solutions to the problems of genetic background and flanking genes.
@ast
Knockout mice: simple solutions to the problems of genetic background and flanking genes.
@en
Knockout mice: simple solutions to the problems of genetic background and flanking genes.
@nl
prefLabel
Knockout mice: simple solutions to the problems of genetic background and flanking genes.
@ast
Knockout mice: simple solutions to the problems of genetic background and flanking genes.
@en
Knockout mice: simple solutions to the problems of genetic background and flanking genes.
@nl
P1476
Knockout mice: simple solutions to the problems of genetic background and flanking genes.
@en
P2093
David P Wolfer
Hans Peter Lipp
P304
P356
10.1016/S0166-2236(02)02192-6
P50
P577
2002-07-01T00:00:00Z