Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.
about
Juvenile myelomonocytic leukemia: molecular pathogenesis informs current approaches to therapy and hematopoietic cell transplantationProtein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesRINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesisMutant Cbl proteins as oncogenic drivers in myeloproliferative disordersIndispensable roles of mammalian Cbl family proteins as negative regulators of protein tyrosine kinase signaling: Insights from in vivo modelsMolecular pathways: cbl proteins in tumorigenesis and antitumor immunity-opportunities for cancer treatment.Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation.A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells.What's different about atypical CML and chronic neutrophilic leukemia?Cbl proteins in platelet activation.Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice.Genetic and epigenetic alterations of myeloproliferative disorders.Modulation of Immune Cell Functions by the E3 Ligase Cbl-b.Mutations of c-Cbl in myeloid malignanciesStructural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN.An essential role of CBL and CBL-B ubiquitin ligases in mammary stem cell maintenance.Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-γc-/- mice.Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy.Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl-b deficiency-driven murine model of myeloproliferative disorders.VAV1-Cre mediated hematopoietic deletion of CBL and CBL-B leads to JMML-like aggressive early-neonatal myeloproliferative disease.High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias.Oncogenic Signaling by Leukemia-Associated Mutant Cbl ProteinsCBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies.CBL mutation-related patterns of phosphorylation and sensitivity to tyrosine kinase inhibitors.CBL-B is required for leukemogenesis mediated by BCR-ABL through negative regulation of bone marrow homing.
P2860
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P2860
Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.
description
2010 nî lūn-bûn
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2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年學術文章
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name
Rapidly fatal myeloproliferati ...... b in hematopoietic stem cells.
@ast
Rapidly fatal myeloproliferati ...... b in hematopoietic stem cells.
@en
Rapidly fatal myeloproliferati ...... ion of Casitas B-cell lymphoma
@nl
type
label
Rapidly fatal myeloproliferati ...... b in hematopoietic stem cells.
@ast
Rapidly fatal myeloproliferati ...... b in hematopoietic stem cells.
@en
Rapidly fatal myeloproliferati ...... ion of Casitas B-cell lymphoma
@nl
prefLabel
Rapidly fatal myeloproliferati ...... b in hematopoietic stem cells.
@ast
Rapidly fatal myeloproliferati ...... b in hematopoietic stem cells.
@en
Rapidly fatal myeloproliferati ...... ion of Casitas B-cell lymphoma
@nl
P2093
P2860
P356
P1476
Rapidly fatal myeloproliferati ...... b in hematopoietic stem cells.
@en
P2093
Hamid Band
Mayumi Naramura
Neha Nandwani
Vimla Band
P2860
P304
16274-16279
P356
10.1073/PNAS.1007575107
P407
P577
2010-08-30T00:00:00Z