Chk1 promotes replication fork progression by controlling replication initiation.
about
Targeting DNA Replication Stress for Cancer TherapyActivation of new replication foci under conditions of replication stress.Checkpoint kinase 1 in DNA damage response and cell cycle regulationThe cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial designRoles of Chk1 in cell biology and cancer therapyDNA damage response genes and the development of cancer metastasisUSP37 deubiquitinates Cdt1 and contributes to regulate DNA replicationUSP7 is a SUMO deubiquitinase essential for DNA replicationCell cycle-dependent localization of CHK2 at centrosomes during mitosis.Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell deathThe Spi1/PU.1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemiaStructure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation.Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers.Chromatin structure and replication origins: determinants of chromosome replication and nuclear organizationThe Mre11 nuclease is critical for the sensitivity of cells to Chk1 inhibition.RAD51AP1-deficiency in vertebrate cells impairs DNA replication.Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1Replication fork integrity and intra-S phase checkpoint suppress gene amplification.The fork and the kinase: a DNA replication tale from a CHK1 perspective.Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphomaPhosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation.Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints.Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability.mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibitionBRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylationCdc45 is limiting for replication initiation in humansKinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA.Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S PhaseInhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase.NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activityCHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiationUnique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibitionRECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures.Characterization of a mantle cell lymphoma cell line resistant to the Chk1 inhibitor PF-00477736Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response.Separation of intra-S checkpoint protein contributions to DNA replication fork protection and genomic stability in normal human fibroblastsThe level of origin firing inversely affects the rate of replication fork progression.Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry.Torin2 Suppresses Ionizing Radiation-Induced DNA Damage RepairFANCJ is essential to maintain microsatellite structure genome-wide during replication stress.
P2860
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P2860
Chk1 promotes replication fork progression by controlling replication initiation.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Chk1 promotes replication fork progression by controlling replication initiation.
@ast
Chk1 promotes replication fork progression by controlling replication initiation.
@en
Chk1 promotes replication fork progression by controlling replication initiation.
@nl
type
label
Chk1 promotes replication fork progression by controlling replication initiation.
@ast
Chk1 promotes replication fork progression by controlling replication initiation.
@en
Chk1 promotes replication fork progression by controlling replication initiation.
@nl
prefLabel
Chk1 promotes replication fork progression by controlling replication initiation.
@ast
Chk1 promotes replication fork progression by controlling replication initiation.
@en
Chk1 promotes replication fork progression by controlling replication initiation.
@nl
P2860
P356
P1476
Chk1 promotes replication fork progression by controlling replication initiation.
@en
P2093
Eva Petermann
Mick Woodcock
P2860
P304
16090-16095
P356
10.1073/PNAS.1005031107
P407
P577
2010-08-30T00:00:00Z