PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
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Acetylation-dependent regulation of Skp2 functionKank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signalingInteraction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destructionFoxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressorPHLiPPing the switch on Akt and protein kinase C signalingRSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.Knockin of mutant PIK3CA activates multiple oncogenic pathwaysAKT/PKB signaling: navigating downstreamPten dose dictates cancer progression in the prostateTransforming growth factor-beta induces Cdk2 relocalization to the cytoplasm coincident with dephosphorylation of retinoblastoma tumor suppressor proteinp27KIP1 phosphorylation by PKB/Akt leads to poor breast cancer prognosisDeregulation of p27 by oncogenic signaling and its prognostic significance in breast cancerStructure of HER receptors and intracellular localisation of downstream effector elements gives insight into mechanism of tumour growth promotionCelecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumoursAutophagy and Apoptotic Crosstalk: Mechanism of Therapeutic Resistance in HER2-Positive Breast CancerMislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapyArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survivalTumor suppressor ARF inhibits HER-2/neu-mediated oncogenic growthConstitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicityInhibition of PI3K/Akt pathway impairs G2/M transition of cell cycle in late developing progenitors of the avian embryo retinaActivation of the insulin-like growth factor-1 receptor alters p27 regulation by the epidermal growth factor receptor in oral squamous carcinoma cellsPreclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomas.Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.p27Kip1 localization depends on the tumor suppressor protein tuberin.A mechanism misregulating p27 in tumors discovered in a functional genomic screen.Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts.Towards a systems biology approach to mammalian cell cycle: modeling the entrance into S phase of quiescent fibroblasts after serum stimulation.Secretin receptor promotes the proliferation of endocrine tumor cells via the PI3K/AKT pathway.Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth.Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids.Akt regulates the expression of MafK, synaptotagmin I, and syntenin-1, which play roles in neuronal function.Fish oil targets PTEN to regulate NFkappaB for downregulation of anti-apoptotic genes in breast tumor growth.Role of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors.EGFR/HER2 inhibitor AEE788 increases ER-mediated transcription in HER2/ER-positive breast cancer cells but functions synergistically with endocrine therapy.Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells.The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cellsAkt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes
P2860
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P2860
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
PKB/Akt mediates cell-cycle progression by phosphorylation of p27
@nl
PKB/Akt mediates cell-cycle pr ...... of its cellular localization.
@ast
PKB/Akt mediates cell-cycle pr ...... of its cellular localization.
@en
type
label
PKB/Akt mediates cell-cycle progression by phosphorylation of p27
@nl
PKB/Akt mediates cell-cycle pr ...... of its cellular localization.
@ast
PKB/Akt mediates cell-cycle pr ...... of its cellular localization.
@en
prefLabel
PKB/Akt mediates cell-cycle progression by phosphorylation of p27
@nl
PKB/Akt mediates cell-cycle pr ...... of its cellular localization.
@ast
PKB/Akt mediates cell-cycle pr ...... of its cellular localization.
@en
P2093
P356
P1433
P1476
PKB/Akt mediates cell-cycle pr ...... of its cellular localization.
@en
P2093
Andrei V Bakin
Carlos L Arteaga
F Michael Yakes
Federico Rojo
Incheol Shin
Nah-Young Shin
P2888
P304
P356
10.1038/NM759
P407
P50
P577
2002-09-16T00:00:00Z
P6179
1007149132