Structural biology of insulin and IGF1 receptors: implications for drug design.
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Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advancesDiscovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197Alanine scanning of a putative receptor binding surface of insulin-like growth factor-IHarmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activationInsulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteomePharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytesThe metabolic and mitogenic properties of basal insulin analoguesHeterodimerization of glycosylated insulin-like growth factor-1 receptors and insulin receptors in cancer cells sensitive to anti-IGF1R antibodyEpitope-specific mechanisms of IGF1R inhibition by ganitumabThe A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related creviceDesign of an Active Ultrastable Single-chain Insulin Analog: SYNTHESIS, STRUCTURE, AND THERAPEUTIC IMPLICATIONSEnhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINSDesign of an Insulin Analog with Enhanced Receptor Binding Selectivity: RATIONALE, STRUCTURE, AND THERAPEUTIC IMPLICATIONSImplications for the active form of human insulin based on the structural convergence of highly active hormone analoguesStructural Basis for Negative Cooperativity in Growth Factor Binding to an EGF ReceptorStructural and Biological Properties of the Drosophila Insulin-like Peptide 5 Show Evolutionary ConservationInsight into the Structural and Biological Relevance of the T/R Transition of the N-Terminus of the B-Chain in Human InsulinProtective hinge in insulin opens to enable its receptor engagementCloning and characterisation of Schistosoma japonicum insulin receptorsThe insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endotheliumInsulin induces calcium signals in the nucleus of rat hepatocytesNuclear targeting of IGF-1 receptor in orbital fibroblasts from Graves' disease: apparent role of ADAM17RILM: a web-based resource to aid comparative and functional analysis of the insulin and IGF-1 receptor family.Aromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.Contribution of TyrB26 to the Function and Stability of Insulin: STRUCTURE-ACTIVITY RELATIONSHIPS AT A CONSERVED HORMONE-RECEPTOR INTERFACE.Conformational dynamics of insulin.Unusual duplication of the insulin-like receptor in the crustacean Daphnia pulex.Novel nuclear localization and potential function of insulin-like growth factor-1 receptor/insulin receptor hybrid in corneal epithelial cellsAll-Atom Structural Models of the Transmembrane Domains of Insulin and Type 1 Insulin-Like Growth Factor ReceptorsIs dynamic autocrine insulin signaling possible? A mathematical model predicts picomolar concentrations of extracellular monomeric insulin within human pancreatic islets.Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chainInhibition of the proteolytic activity of pregnancy-associated plasma protein-A by targeting substrate exosite binding.Insulin/receptor binding: the last piece of the puzzle? What recent progress on the structure of the insulin/receptor complex tells us (or not) about negative cooperativity and activation.A comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information.In vitro metabolic and mitogenic signaling of insulin glargine and its metabolitesDiscovery of an Orally Efficacious Imidazo[5,1-f][1,2,4]triazine Dual Inhibitor of IGF-1R and IR.The complexity of the IGF1 gene splicing, posttranslational modification and bioactivityNovel tools for prostate cancer prognosis, diagnosis, and follow-upAcute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathwaysHigh-affinity insulin binding: insulin interacts with two receptor ligand binding sites.
P2860
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P2860
Structural biology of insulin and IGF1 receptors: implications for drug design.
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Structural biology of insulin and IGF1 receptors: implications for drug design.
@ast
Structural biology of insulin and IGF1 receptors: implications for drug design.
@en
Structural biology of insulin and IGF1 receptors: implications for drug design.
@nl
type
label
Structural biology of insulin and IGF1 receptors: implications for drug design.
@ast
Structural biology of insulin and IGF1 receptors: implications for drug design.
@en
Structural biology of insulin and IGF1 receptors: implications for drug design.
@nl
prefLabel
Structural biology of insulin and IGF1 receptors: implications for drug design.
@ast
Structural biology of insulin and IGF1 receptors: implications for drug design.
@en
Structural biology of insulin and IGF1 receptors: implications for drug design.
@nl
P356
P1476
Structural biology of insulin and IGF1 receptors: implications for drug design.
@en
P2093
Jonathan Whittaker
P2888
P304
P356
10.1038/NRD917
P577
2002-10-01T00:00:00Z