Identification of a potent and orally active non-peptide C5a receptor antagonist. - Wikidata - awgldk - TriplyDB

Identification of a potent and orally active non-peptide C5a receptor antagonist.

Identification of a potent and orally active non-peptide C5a receptor antagonist.

http://www.wikidata.org/entity/Q34154819

about

Function, structure and therapeutic potential of complement C5a receptors C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism Identification of novel natural compound inhibitors for human complement component 5a receptor by homology modeling and virtual screening The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Autocrine effects of tumor-derived complement.Retrieving novel C5aR antagonists using a hybrid ligand-based virtual screening protocol based on SVM classification and pharmacophore models.Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.Differential Interaction of the Staphylococcal Toxins Panton-Valentine Leukocidin and γ-Hemolysin CB with Human C5a Receptors Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis Novel C5a regulators in inflammatory disease.Recent developments in low molecular weight complement inhibitors C5a receptor (CD88) promotes motility and invasiveness of gastric cancer by activating RhoA.The role of the ribosomal protein S19 C-terminus in altering the chemotaxis of leucocytes by causing functional differences in the C5a receptor response.C5a promotes migration, proliferation, and vessel formation in endothelial cells Molecular characterization of the gerbil C5a receptor and identification of a transmembrane domain V amino acid that is crucial for small molecule antagonist interaction.Contribution of anaphylatoxins to allergic inflammation in human lungs.Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727.Mesenchymal Stem Cells Control Complement C5 Activation by Factor H in Lupus Nephritis.Internalization of staphylococcal leukotoxins that bind and divert the C5a receptor is required for intracellular Ca2+mobilization by human neutrophils

P2860

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P2860

Identification of a potent and orally active non-peptide C5a receptor antagonist.

http://www.wikidata.org/entity/Q34154819

description

2002 nî lūn-bûn

@nan

2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2002年の論文

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2002年論文

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2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

@wuu

name

Identification of a potent and orally active non-peptide C5a receptor antagonist.

@ast

Identification of a potent and orally active non-peptide C5a receptor antagonist.

@en

Identification of a potent and orally active non-peptide C5a receptor antagonist.

@nl

type

label

Identification of a potent and orally active non-peptide C5a receptor antagonist.

@ast

Identification of a potent and orally active non-peptide C5a receptor antagonist.

@en

Identification of a potent and orally active non-peptide C5a receptor antagonist.

@nl

prefLabel

Identification of a potent and orally active non-peptide C5a receptor antagonist.

@ast

Identification of a potent and orally active non-peptide C5a receptor antagonist.

@en

Identification of a potent and orally active non-peptide C5a receptor antagonist.

@nl

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P1433

Journal of Biological Chemistry

P1476

Identification of a potent and orally active non-peptide C5a receptor antagonist.

@en

P2093

Hiroshi Sumichika

http://www.w3.org/2001/XMLSchema#string

Hirotsugu Komatsu

http://www.w3.org/2001/XMLSchema#string

Katsuhiko Itoh

http://www.w3.org/2001/XMLSchema#string

Kei Sakata

http://www.w3.org/2001/XMLSchema#string

Mitsuharu Nakamura

http://www.w3.org/2001/XMLSchema#string

Noriko Sato

http://www.w3.org/2001/XMLSchema#string

Sanae Takeshita

http://www.w3.org/2001/XMLSchema#string

Seigo Ishibuchi

http://www.w3.org/2001/XMLSchema#string

Syuji Ehara

http://www.w3.org/2001/XMLSchema#string

Tadashi Mishina

http://www.w3.org/2001/XMLSchema#string

P2860

C5A anaphylatoxin and its seven transmembrane-segment receptor

Molecular cloning and expression of the functional rat C5a receptor

A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats

Cloning and characterization of the guinea pig C5a anaphylatoxin receptor: interspecies diversity among the C5a receptors.

Cloning and functional expression of the canine anaphylatoxin C5a receptor. Evidence for high interspecies variability.

Measurement of the chemotactic complement fragment C5a in rheumatoid synovial fluids by radioimmunoassay: role of C5a in the acute inflammatory phase.

Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease.

Focal inflammation in the brain: role in Alzheimer's disease.

Complement components of the innate immune system in health and disease in the CNS.

Targeting complement in therapy.

P304

49403-49407

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scholarly article

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10.1074/JBC.M209672200

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P433

51

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P478

277

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2002-10-15T00:00:00Z

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P698

12384495

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