Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.
about
A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancyDrug-Target Kinetics in Drug Discovery.Binding Thermodynamics and Kinetics Calculations Using Chemical Host and Guest: A Comprehensive Picture of Molecular Recognition.Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis.Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice.Protein-ligand (un)binding kinetics as a new paradigm for drug discovery at the crossroad between experiments and modelling
P2860
Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.
description
2016 nî lūn-bûn
@nan
2016 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Receptor residence time trumps ...... of complement C5a antagonists.
@ast
Receptor residence time trumps ...... of complement C5a antagonists.
@en
Receptor residence time trumps ...... of complement C5a antagonists.
@nl
type
label
Receptor residence time trumps ...... of complement C5a antagonists.
@ast
Receptor residence time trumps ...... of complement C5a antagonists.
@en
Receptor residence time trumps ...... of complement C5a antagonists.
@nl
prefLabel
Receptor residence time trumps ...... of complement C5a antagonists.
@ast
Receptor residence time trumps ...... of complement C5a antagonists.
@en
Receptor residence time trumps ...... of complement C5a antagonists.
@nl
P2093
P2860
P50
P356
P1433
P1476
Receptor residence time trumps ...... of complement C5a antagonists
@en
P2093
Adam J Cotterell
Vernon Seow
P2860
P2888
P356
10.1038/SREP24575
P407
P50
P577
2016-04-20T00:00:00Z
P5875
P6179
1002426978