17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development. - Wikidata - awgldk - TriplyDB

17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development.

17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development.

http://www.wikidata.org/entity/Q34156987

about

Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases The structural biology of oestrogen metabolism Insights into subtle conformational differences in the substrate-binding loop of fungal 17β-hydroxysteroid dehydrogenase: a combined structural and kinetic approach Activity of Zearalenone in the Porcine Intestinal Tract The Effect of Low Monotonic Doses of Zearalenone on Selected Reproductive Tissues in Pre-Pubertal Female Dogs--A Review Structural basis for species specific inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1): computational study and biological validation Hydroxybenzothiazoles as new nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1)Engineering Mycobacterium smegmatis for testosterone production Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease.Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases.Disrupting KATP channels diminishes the estrogen-mediated protection in female mutant mice during ischemia-reperfusion.Male-dominant activation of rat renal organic anion transporter 1 (Oat1) and 3 (Oat3) expression by transcription factor BCL6 Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights.Overexpression of aromatase alone is sufficient for ovarian development in genetically male chicken embryos Human hydroxysteroid dehydrogenases and pre-receptor regulation: insights into inhibitor design and evaluation.Synthesis of halogenated pregnanes, mechanistic probes of steroid hydroxylases CYP17A1 and CYP21A2.Endometrial and endometriotic concentrations of estrone and estradiol are determined by local metabolism rather than circulating levels.The sulfatase pathway for estrogen formation: targets for the treatment and diagnosis of hormone-associated tumors.Regulation of 17β-hydroxysteroid dehydrogenases in cancer: regulating steroid receptor at pre-receptor stage.Crucial Role of 3-Bromoethyl in Removing the Estrogenic Activity of 17β-HSD1 Inhibitor 16β-(m-Carbamoylbenzyl)estradiol.A role for the dehydrogenase DHRS7 (SDR34C1) in prostate cancer.Synthesis of novel 13α-estrone derivatives by Sonogashira coupling as potential 17β-HSD1 inhibitors.QSAR Study of 17β-HSD3 Inhibitors by Genetic Algorithm-Support Vector Machine as a Target Receptor for the Treatment of Prostate Cancer.Deleting the mouse Hsd17b1 gene results in a hypomorphic Naglu allele and a phenotype mimicking a lysosomal storage disease.Synthesis and Biological Evaluation of Triazolyl 13α-Estrone-Nucleoside Bioconjugates.Comparative investigation of the in vitro inhibitory potencies of 13-epimeric estrones and D-secoestrones towards 17β-hydroxysteroid dehydrogenase type 1.Biological activity of pyrazole and imidazole-dehydroepiandrosterone derivatives on the activity of 17β-hydroxysteroid dehydrogenase.Direct antiproliferative effect of nonsteroidal 17β-hydroxysteroid dehydrogenase type 1 inhibitors in vitro.The first Pd-catalyzed Buchwald–Hartwig aminations at C-2 or C-4 in the estrone series.Cohort Profile: the Predictors of Breast Cancer Recurrence (ProBe CaRE) Premenopausal Breast Cancer Cohort Study in Denmark Synthesis and structure-activity relationships of 2- and/or 4-halogenated 13β- and 13α-estrone derivatives as enzyme inhibitors of estrogen biosynthesis

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17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development.

http://www.wikidata.org/entity/Q34156987

description

2010 nî lūn-bûn

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2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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17β-Hydroxysteroid dehydrogena ...... ress in inhibitor development.

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17β-Hydroxysteroid dehydrogena ...... ress in inhibitor development.

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17β-Hydroxysteroid dehydrogena ...... ress in inhibitor development.

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17β-Hydroxysteroid dehydrogena ...... ress in inhibitor development.

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17β-Hydroxysteroid dehydrogena ...... ress in inhibitor development.

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J.JSBMB.2010.12.013

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The Journal of Steroid Biochemistry and Molecular Biology

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17β-Hydroxysteroid dehydrogena ...... gress in inhibitor development

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Alessandro Spadaro

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Alexander Oster

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Claudia Henn

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Jerzy Adamski

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Kuiying Xu

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Marie Wetzel

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Rolf W Hartmann

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Ruth Werth

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66-82

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scholarly article

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10.1016/J.JSBMB.2010.12.013

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1-2

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125

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Gabriele Möller

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2010-12-28T00:00:00Z

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21193039

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