The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.
about
Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosisThe de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signalingOrigin and function of ubiquitin-like proteinsMutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson diseaseUbiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunctionLong Non-coding RNAs in the CytoplasmIt Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer DiseaseThe Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer's Disease and Spinal Cord InjuryCell Adhesion Molecules and Ubiquitination-Functions and SignificanceEndoplasmic Reticulum Stress Interacts With Inflammation in Human DiseasesThe role of deubiquitinating enzymes in synaptic function and nervous system diseasesGenetically engineered mouse models of Parkinson's diseaseRoles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degenerationCorticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 FunctionCrystal structure of human DJ-1, a protein associated with early onset Parkinson's diseaseUbiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformationThe deubiquitinating enzyme Ubp1 affects sorting of the ATP-binding cassette-transporter Ste6 in the endocytic pathway.Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative DiseasesEssential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteinsAmino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8)Pesticides, microglial NOX2, and Parkinson's diseaseHypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin geneUSP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1Excess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1Heterogeneous expression and functional relevance of the ubiquitin carboxyl-terminal hydrolase L1 in melanoma.The UCHL1 S18Y polymorphism and Parkinson's disease in a Japanese population.The expression and significance of neuronal iconic proteins in podocytes.Replaceable neurons and neurodegenerative disease share depressed UCHL1 levelsOver-expression of ubiquitin carboxy terminal hydrolase-L1 induces apoptosis in breast cancer cells.Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signalingExpression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genesGenome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development.Mass spectrometry assessment of ubiquitin carboxyl-terminal hydrolase L1 partitioning between soluble and particulate brain homogenate fractionsLack of evidence for an association between UCHL1 S18Y and Parkinson's disease.Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junctionModelling the role of UCH-L1 on protein aggregation in age-related neurodegeneration.In vivo transduction of neurons with TAT-UCH-L1 protects brain against controlled cortical impact injury.Specific interaction between Sam68 and neuronal mRNAs: implication for the activity-dependent biosynthesis of elongation factor eEF1A.A system-based comparison of gene expression reveals alterations in oxidative stress, disruption of ubiquitin-proteasome system and altered cell cycle regulation after exposure to cadmium and methylmercury in mouse embryonic fibroblast.Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease.
P2860
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P2860
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The UCH-L1 gene encodes two op ...... nson's disease susceptibility.
@ast
The UCH-L1 gene encodes two op ...... nson's disease susceptibility.
@en
The UCH-L1 gene encodes two op ...... nson's disease susceptibility.
@nl
type
label
The UCH-L1 gene encodes two op ...... nson's disease susceptibility.
@ast
The UCH-L1 gene encodes two op ...... nson's disease susceptibility.
@en
The UCH-L1 gene encodes two op ...... nson's disease susceptibility.
@nl
prefLabel
The UCH-L1 gene encodes two op ...... nson's disease susceptibility.
@ast
The UCH-L1 gene encodes two op ...... nson's disease susceptibility.
@en
The UCH-L1 gene encodes two op ...... nson's disease susceptibility.
@nl
P2093
P1433
P1476
The UCH-L1 gene encodes two op ...... nson's disease susceptibility.
@en
P2093
Lara Fallon
Peter T Lansbury
Yichin Liu
Zhihua Liu
P304
P356
10.1016/S0092-8674(02)01012-7
P407
P577
2002-10-01T00:00:00Z