Varied Molecular Interactions at the Active Sites of Several DNA Polymerases: Nonpolar Nucleoside Isosteres as Probes. - Wikidata - awgldk - TriplyDB

Varied Molecular Interactions at the Active Sites of Several DNA Polymerases: Nonpolar Nucleoside Isosteres as Probes.

Varied Molecular Interactions at the Active Sites of Several DNA Polymerases: Nonpolar Nucleoside Isosteres as Probes.

http://www.wikidata.org/entity/Q34157423

about

Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase alpha Sequence determination of nucleic acids containing 5-methylisocytosine and isoguanine: identification and insight into polymerase replication of the non-natural nucleobases The use of thymidine analogs to improve the replication of an extra DNA base pair: a synthetic biological system.Antimutator variants of DNA polymerases Solution Structure, Mechanism of Replication, and Optimization of an Unnatural Base Pair Probing Minor Groove Hydrogen Bonding Interactions between RB69 DNA Polymerase and DNA Synthesis and properties of oligonucleotides containing 5-formyl-2'-deoxycytidine: in vitro DNA polymerase reactions on DNA templates containing 5-formyl-2'-deoxycytidine.Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selection A mass spectrometry-based approach for identifying novel DNA polymerase substrates from a pool of dNTP analogues Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity Evidence for a Watson-Crick hydrogen bonding requirement in DNA synthesis by human DNA polymerase kappa Discovery, characterization, and optimization of an unnatural base pair for expansion of the genetic alphabet.A new, but old, nucleoside analog: the first synthesis of 1-deaza-2'-deoxyguanosine and its properties as a nucleoside and as oligodeoxynucleotides Unnatural substrate repertoire of A, B, and X family DNA polymerases.High-fidelity in vivo replication of DNA base shape mimics without Watson-Crick hydrogen bonds.Requirement of Watson-Crick hydrogen bonding for DNA synthesis by yeast DNA polymerase eta.Roles of Watson-Crick and minor groove hydrogen bonds in DNA replication.Site-directed mutagenesis in the fingers subdomain of HIV-1 reverse transcriptase reveals a specific role for the beta3-beta4 hairpin loop in dNTP selection.Mechanism of template-independent nucleotide incorporation catalyzed by a template-dependent DNA polymerase Unnatural base pairs for specific transcription.The difluorotoluene debate--a decade later.The expanded genetic alphabet.Identifying the features of purine dNTPs that allow accurate and efficient DNA replication by herpes simplex virus I DNA polymerase.Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate Exploring the effects of active site constraints on HIV-1 reverse transcriptase DNA polymerase fidelity.Reverse transcriptase incorporation of 1,5-anhydrohexitol nucleotides.Thermodynamic stability of base pairs between 2-hydroxyadenine and incoming nucleotides as a determinant of nucleotide incorporation specificity during replication Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus.Nucleotide Analogues as Probes for DNA and RNA Polymerases.Dynamics of nucleotide incorporation: snapshots revealed by 2-aminopurine fluorescence studies.The fidelity of replication of the three-base-pair set adenine/thymine, hypoxanthine/cytosine and 6-thiopurine/5-methyl-2-pyrimidinone with T7 DNA polymerase.DNA polymerase catalysis in the absence of Watson-Crick hydrogen bonds: analysis by single-turnover kinetics.Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity.Computer simulation studies of the fidelity of DNA polymerases.Computational Evaluation of Nucleotide Insertion Opposite Expanded and Widened DNA by the Translesion Synthesis Polymerase Dpo4.B-DNA structure and stability: the role of hydrogen bonding, π–π stacking interactions, twist-angle, and solvation Selectivity in DNA replication. Interplay of steric shape, hydrogen bonds, π-stacking and solvent effects

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P2860

Varied Molecular Interactions at the Active Sites of Several DNA Polymerases: Nonpolar Nucleoside Isosteres as Probes.

http://www.wikidata.org/entity/Q34157423

description

2000 nî lūn-bûn

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2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2000 թվականի փետրվարին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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Varied Molecular Interactions ...... ucleoside Isosteres as Probes.

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Journal of the American Chemical Society

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Varied Molecular Interactions ...... ucleoside Isosteres as Probes.

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Eric T Kool

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Juan C Morales

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P2860

Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

Structure of DNA polymerase I Klenow fragment bound to duplex DNA

Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase

Structure of Taq polymerase with DNA at the polymerase active site

Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69

Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution

Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli

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