Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity. - Wikidata - awgldk - TriplyDB

Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity.

Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity.

http://www.wikidata.org/entity/Q43833668

about

DNA polymerase family X: function, structure, and cellular roles Structures of DNA Polymerase β with Active-Site Mismatches Suggest a Transient Abasic Site Intermediate during Misincorporation α,β-Difluoromethylene Deoxynucleoside 5′-Triphosphates: A Convenient Synthesis of Useful Probes for DNA Polymerase β Structure and Function DNA Polymerase Substrate Specificity: SIDE CHAIN MODULATION OF THE"A-RULE"Molecular Insights into DNA Polymerase Deterrents for Ribonucleotide Insertion Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction Observing a DNA Polymerase Choose Right from Wrong The E295K Cancer Variant of Human Polymerase Favors the Mismatch Conformational Pathway during Nucleotide Selection Structure and mechanism of DNA polymerase β Phylogenetic analysis and evolutionary origins of DNA polymerase X-family members Structural comparison of DNA polymerase architecture suggests a nucleotide gateway to the polymerase active site.Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT.DNA polymerase beta ribonucleotide discrimination: insertion, misinsertion, extension, and coding.Highly organized but pliant active site of DNA polymerase beta: compensatory mechanisms in mutant enzymes revealed by dynamics simulations and energy analyses.Modeling DNA polymerase μ motions: subtle transitions before chemistry.Substrate-induced DNA polymerase β activation.DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine.Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells.Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide Sequential side-chain residue motions transform the binary into the ternary state of DNA polymerase lambda.Loop II of DNA polymerase beta is important for polymerization activity and fidelity.Metal-induced DNA translocation leads to DNA polymerase conformational activation.Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase beta.Exploring the role of large conformational changes in the fidelity of DNA polymerase beta Multifactor dimensionality reduction analysis identifies specific nucleotide patterns promoting genetic polymorphisms.Sequence context-specific mutagenesis and base excision repair.Insights into the conformation of aminofluorene-deoxyguanine adduct in a DNA polymerase active site.Understanding the loss-of-function in a triple missense mutant of DNA polymerase β found in prostate cancer.Translesion DNA synthesis in the context of cancer research.Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer.DNA polymerase beta catalytic efficiency mirrors the Asn279-dCTP H-bonding strength.Kinetic effect of a downstream strand and its 5'-terminal moieties on single nucleotide gap-filling synthesis catalyzed by human DNA polymerase lambda.Efficiency of correct nucleotide insertion governs DNA polymerase fidelity.Using 2-aminopurine fluorescence to measure incorporation of incorrect nucleotides by wild type and mutant bacteriophage T4 DNA polymerases.Genomic analysis of cancer tissue reveals that somatic mutations commonly occur in a specific motif.A binding free energy decomposition approach for accurate calculations of the fidelity of DNA polymerases.Systematic biochemical analysis of somatic missense mutations in DNA polymerase β found in prostate cancer reveal alteration of enzymatic function Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells.Rapid segmental and subdomain motions of DNA polymerase beta.Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis.

P2860

Q24612173-D6BBDCD3-3600-40BC-A333-DB8F8985B88C Q27650580-DFFE4098-7E39-4BF1-869D-C788F648930D Q27654568-B4D6D229-4C50-4523-83EE-3FB5AFB094DA Q27657443-3506193C-3923-4A9A-BAE1-3E2634EDEF42 Q27670712-489432D0-D05B-4490-9DD6-B495BE8F075F Q27678004-6757B6AC-D88E-415F-9716-8D4069B6A11A Q27678932-8E36A662-FB99-4965-AD59-B86B8A625BFA Q27680388-9233D38F-3288-4B61-A04E-87810D46AE6A Q28237870-D1C75F3C-934E-4C6B-816F-8CEAA48F7390 Q28650159-FBD2444D-E3DC-4C92-A7DA-394DF72F017B Q33597718-70F45654-1283-405A-BA23-F8C5C16ED9C1 Q33966716-F9CEF5B5-54EA-430B-B544-EE50426C7B80 Q34042552-F9266BD8-5CE6-4143-AF59-130D47E45BFF Q34185910-9CC70816-034F-43CD-BDD4-4E56426A03B2 Q34306952-668A8155-3F8A-4795-BC08-07594A5654F5 Q34467634-F6A6965E-0EC1-4F0E-89F1-D5273AEAEBC6 Q34504919-F3AA5F0D-2C9C-4FB8-8E9B-9DBF3E8827C5 Q34522600-9E1BA436-ABAB-4343-A0FF-AC7AACC97A8D Q35032502-0A580390-34AD-4864-A022-91CE45979408 Q35095792-92253F42-F549-4960-9784-12FE212EA264 Q35837379-50D1734B-B112-4E00-B0E1-A709BE571331 Q35888841-C7ED68FC-3CF9-40A7-859C-16B6DB5BDF8F Q36557917-31A378EB-B491-4097-B397-1A754240DC10 Q36627376-11E56731-D276-4529-B916-7092F6F376C0 Q37158531-71BBD69D-B925-4909-96CA-0D1D89AB8FE0 Q37420606-104850B6-18DF-44CF-A524-4E1DD7C3A6D0 Q37629795-04DB68D4-D7EF-45B7-9245-A254835A59F7 Q37693925-2EA8F439-DCEA-4E47-A6FD-8FEF2D7C1245 Q37952001-B898CA1C-B051-41EB-ADFC-C68478340CDC Q38026112-5FD57196-9CCC-4CBD-9CED-55437DB136B3 Q38304989-32100489-708A-4521-A1F7-7B59FBB07B23 Q38309158-B0BBED3E-BCCA-46A6-8CBF-483237019828 Q38362195-F2623444-6DF7-4CC7-A7E2-943B5967A850 Q38363604-57B4F0EA-754E-4BF1-997B-125B752E9529 Q41812715-CB04B426-C06D-41B0-AB53-5F69C556C7CF Q41867652-81EB691E-675E-4C2D-86F8-FD9A1A7E235F Q42700256-48FDC33E-E89E-4971-A0EE-652163A7CED3 Q42831362-7C8BD7FF-DA70-49F7-8644-B3C6DB6E0294 Q44233714-A799C5CB-9768-4A4A-9584-872146ABC06F Q44460153-831F2D8B-EF26-45C3-AE4B-E007147DADC1

P2860

Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity.

http://www.wikidata.org/entity/Q43833668

description

2001 nî lūn-bûn

@nan

2001年の論文

@ja

2001年学术文章

@wuu

2001年学术文章

@zh

2001年学术文章

@zh-cn

2001年学术文章

@zh-hans

2001年学术文章

@zh-my

2001年学术文章

@zh-sg

2001年學術文章

@yue

2001年學術文章

@zh-hant

name

Loss of DNA polymerase beta st ...... lytic efficiency and fidelity.

@en

Loss of DNA polymerase beta st ...... lytic efficiency and fidelity.

@nl

type

label

Loss of DNA polymerase beta st ...... lytic efficiency and fidelity.

@en

Loss of DNA polymerase beta st ...... lytic efficiency and fidelity.

@nl

prefLabel

Loss of DNA polymerase beta st ...... lytic efficiency and fidelity.

@en

Loss of DNA polymerase beta st ...... lytic efficiency and fidelity.

@nl

P1433

Q43833668-D084BD8C-DBB3-49EA-AF93-511ECF3F4C35

P1476

Q43833668-A8113FF3-73AE-49A0-A7AE-44349D3AE7C5

P2093

Q43833668-01106ADB-9445-4467-9E33-EB833FA4C5E2

Q43833668-A8D225C0-86C0-4EB3-8EAD-4A7AD7E119FE

Q43833668-D55F2C5B-81B5-4933-BBEE-16446DE31F85

Q43833668-EBC742D8-65C1-4F8A-9200-03BCCA743518

P2860

Q43833668-14DB09E2-A9BB-4B56-B8D9-E8FD6BCEBFA1

Q43833668-189C6935-99B6-400A-AE99-FA44919AD22C

Q43833668-1CA0FBA9-65B1-4835-A01C-AC326BD8E9D1

Q43833668-25FE7DC1-9EF5-42F5-AEE9-AEF8DD5ED323

Q43833668-3055D1DC-BD7A-4B06-8C7B-55BA5A588DA6

Q43833668-3295E824-0860-4431-94AE-52885ABF620A

Q43833668-512859FF-5112-454B-B232-7B5FF966B04F

Q43833668-53623AF4-BD25-421B-BE79-84D80D038E26

Q43833668-54EF9676-77C7-49D7-BDFD-267F31FE37A9

Q43833668-714F2E65-E241-4847-8600-9CC41EE9449E

P304

Q43833668-67A0CB38-DDEA-4FA2-9D78-26ED8CE2AA9E

P31

Q43833668-26A71398-F5D4-4BF2-8482-75A46E9348B8

P356

Q43833668-C814BCE8-8A61-4D1A-8CD6-1559253FBA16

P407

Q43833668-5FC1D637-5B53-418F-BAC2-AAA5E03FB059

P433

Q43833668-7C3A46D3-54FC-4721-BEB7-407946EE7650

P478

Q43833668-1265A7E7-5E75-4F5D-9A5F-7DE1EE4BDD38

P50

Q43833668-03C0B7CD-24EC-4B94-B089-C529E297E1A1

P577

Q43833668-EFF96427-6ECE-4A84-AB97-27BE61F5AC4E

P698

Q43833668-F3C1D72D-490D-4513-878B-4DA4448C2B39

P356

P1433

Journal of Biological Chemistry

P1476

Loss of DNA polymerase beta st ...... alytic efficiency and fidelity

@en

P2093

David D Shock

http://www.w3.org/2001/XMLSchema#string

Saundra F DeLauder

http://www.w3.org/2001/XMLSchema#string

William A Beard

http://www.w3.org/2001/XMLSchema#string

Xiao-Ping Yang

http://www.w3.org/2001/XMLSchema#string

P2860

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

Structure of the replicating complex of a pol alpha family DNA polymerase

Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism

A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta

Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution

Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal

P304

8235-8242

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M107286200

http://www.w3.org/2001/XMLSchema#string

P407

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

277

http://www.w3.org/2001/XMLSchema#string

P50

Samuel H. Wilson

P577

2001-12-26T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

11756435

http://www.w3.org/2001/XMLSchema#string