Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers.
about
Mechanism of cancer cell death induced by depletion of an essential replication regulatorTethering of SCF(Dia2) to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase.The role of Dbf4-dependent protein kinase in DNA polymerase ζ-dependent mutagenesis in Saccharomyces cerevisiae.Quantitative proteomics reveals a "poised quiescence" cellular state after triggering the DNA replication origin activation checkpoint.Subcellular proteomics reveals a role for nucleo-cytoplasmic trafficking at the DNA replication origin activation checkpointIdentification of potential synthetic lethal genes to p53 using a computational biology approachMolecular genetic study of novel biomarkers for early diagnosis of oral squamous cell carcinomaCdc7 overexpression is an independent prognostic marker and a potential therapeutic target in colorectal cancer.Cdc7 is a potent anti-cancer target in pancreatic cancer due to abrogation of the DNA origin activation checkpointCandida albicans Dbf4-dependent Cdc7 kinase plays a novel role in the inhibition of hyphal development.Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness.Pregnancy-associated plasma protein A regulates mitosis and is epigenetically silenced in breast cancer.3D Pharmacophore Model-Assisted Discovery of Novel CDC7 Inhibitors.Molecular architecture of the DNA replication origin activation checkpoint.p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress.Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1.Guanylate-binding protein-1 is a potential new therapeutic target for triple-negative breast cancer.The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy.
P2860
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P2860
Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers.
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2010 nî lūn-bûn
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2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2010 թվականի օգոստոսին հրատարակված գիտական հոդված
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2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年學術文章
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Targeting DNA replication befo ...... in p53-mutant breast cancers.
@ast
Targeting DNA replication befo ...... in p53-mutant breast cancers.
@en
Targeting DNA replication befo ...... in p53-mutant breast cancers.
@nl
type
label
Targeting DNA replication befo ...... in p53-mutant breast cancers.
@ast
Targeting DNA replication befo ...... in p53-mutant breast cancers.
@en
Targeting DNA replication befo ...... in p53-mutant breast cancers.
@nl
prefLabel
Targeting DNA replication befo ...... in p53-mutant breast cancers.
@ast
Targeting DNA replication befo ...... in p53-mutant breast cancers.
@en
Targeting DNA replication befo ...... in p53-mutant breast cancers.
@nl
P2093
P2860
P1476
Targeting DNA replication befo ...... t in p53-mutant breast cancers
@en
P2093
Alex Wollenschlaeger
Gareth H Williams
Ian Proctor
Kai Stoeber
Marco Loddo
Mary Falzon
Mohammed Rashid
Richard Sainsbury
P2860
P304
P356
10.2353/AJPATH.2010.100421
P407
P577
2010-08-19T00:00:00Z