Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum.
about
Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual ScreeningA Multilayer Network Approach for Guiding Drug Repositioning in Neglected DiseasesAminopeptidase N1 (EtAPN1), an M1 metalloprotease of the apicomplexan parasite Eimeria tenella, participates in parasite development.An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling.Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling.A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acidsA structural insight into the P1S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases.The Staphylococcus aureus leucine aminopeptidase is localized to the bacterial cytosol and demonstrates a broad substrate range that extends beyond leucine3,4-Dihydroxyphenylalanine Peptides as Nonperturbative Quantum Dot Sensors of Aminopeptidase.From crystal to compound: structure-based antimalarial drug discovery.Emerging challenges in the design of selective substrates, inhibitors and activity-based probes for indistinguishable proteases.Proteases as antimalarial targets: strategies for genetic, chemical, and therapeutic validation.Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool.Biochemical characterization of aminopeptidase N2 from Toxoplasma gondii.Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo.Two cap residues in the S1 subsite of a Plasmodium falciparum M1-family aminopeptidase promote broad specificity and enhance catalysis.Metallopeptidases of Toxoplasma gondii: in silico identification and gene expression.Fitness Loss under Amino Acid Starvation in Artemisinin-Resistant Plasmodium falciparum Isolates from Cambodia
P2860
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P2860
Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum.
description
2012 nî lūn-bûn
@nan
2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Fingerprinting the substrate s ...... alaria, Plasmodium falciparum.
@ast
Fingerprinting the substrate s ...... alaria, Plasmodium falciparum.
@en
Fingerprinting the substrate s ...... alaria, Plasmodium falciparum.
@nl
type
label
Fingerprinting the substrate s ...... alaria, Plasmodium falciparum.
@ast
Fingerprinting the substrate s ...... alaria, Plasmodium falciparum.
@en
Fingerprinting the substrate s ...... alaria, Plasmodium falciparum.
@nl
prefLabel
Fingerprinting the substrate s ...... alaria, Plasmodium falciparum.
@ast
Fingerprinting the substrate s ...... alaria, Plasmodium falciparum.
@en
Fingerprinting the substrate s ...... alaria, Plasmodium falciparum.
@nl
P2093
P2860
P50
P921
P1433
P1476
Fingerprinting the substrate s ...... alaria, Plasmodium falciparum.
@en
P2093
Donald L Gardiner
Guy S Salvesen
John P Dalton
Katharine R Trenholme
Marcin Drag
Marcin Poreba
Tina S Skinner-Adams
P2860
P304
P356
10.1371/JOURNAL.PONE.0031938
P407
P577
2012-02-16T00:00:00Z